Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion
UNSPECIFIED. (2006) Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion. REACTIVE & FUNCTIONAL POLYMERS, 66 (1). pp. 51-64. ISSN 1381-5148Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.reactfunctpolym.2005.0...
The synthesis of 3-, 5- and 8-arm dimethylaminoethyl methacrylate star polymers are reported, final M. (PDI) = 12.2 K (1.09), 18.9K (1. 10) and 38.4 K (1. 11), respectively. The synthesis of 3-arm methyl methacrylate and dimethylaminoethyl methacrylate block co-polymer stars is also described. Living polymerisation occurred in all cases providing well defined stars with predictable molecular weights and narrow polydispersity. A fluorescent tag, 2-(8-methacryloyloy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoquinoline-1,3-dione, derived from a commercially available pigment, was incorporated into the star polymers. The fluorescence spectra of the polymers prepared were recorded over a range of pH and the peak emission frequency and intensity have been reported, lambda(ex) = 462 nm. All of the multi-arm polymers exhibit fluorescence across a broad pH range with maximum emission at pH 4. A 3-arm star polymer has been demonstrated to show good bioadhesion in rat tissue. A reduced adhesion in epithelial tissues not covered by a viscoelastic mucus gel indicates an increased tendency for mucoadhesion over bioadhesion. (c) 2005 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
T Technology > TP Chemical technology
|Journal or Publication Title:||REACTIVE & FUNCTIONAL POLYMERS|
|Publisher:||ELSEVIER SCIENCE BV|
|Number of Pages:||14|
|Page Range:||pp. 51-64|
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