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Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion
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UNSPECIFIED (2006) Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion. REACTIVE & FUNCTIONAL POLYMERS, 66 (1). pp. 51-64. doi:10.1016/j.reactfunctpolym.2005.07.024 ISSN 1381-5148.
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Official URL: http://dx.doi.org/10.1016/j.reactfunctpolym.2005.0...
Abstract
The synthesis of 3-, 5- and 8-arm dimethylaminoethyl methacrylate star polymers are reported, final M. (PDI) = 12.2 K (1.09), 18.9K (1. 10) and 38.4 K (1. 11), respectively. The synthesis of 3-arm methyl methacrylate and dimethylaminoethyl methacrylate block co-polymer stars is also described. Living polymerisation occurred in all cases providing well defined stars with predictable molecular weights and narrow polydispersity. A fluorescent tag, 2-(8-methacryloyloy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoquinoline-1,3-dione, derived from a commercially available pigment, was incorporated into the star polymers. The fluorescence spectra of the polymers prepared were recorded over a range of pH and the peak emission frequency and intensity have been reported, lambda(ex) = 462 nm. All of the multi-arm polymers exhibit fluorescence across a broad pH range with maximum emission at pH 4. A 3-arm star polymer has been demonstrated to show good bioadhesion in rat tissue. A reduced adhesion in epithelial tissues not covered by a viscoelastic mucus gel indicates an increased tendency for mucoadhesion over bioadhesion. (c) 2005 Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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Journal or Publication Title: | REACTIVE & FUNCTIONAL POLYMERS | ||||
Publisher: | ELSEVIER SCIENCE BV | ||||
ISSN: | 1381-5148 | ||||
Official Date: | January 2006 | ||||
Dates: |
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Volume: | 66 | ||||
Number: | 1 | ||||
Number of Pages: | 14 | ||||
Page Range: | pp. 51-64 | ||||
DOI: | 10.1016/j.reactfunctpolym.2005.07.024 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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