UNSPECIFIED. (2006) Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion. REACTIVE & FUNCTIONAL POLYMERS, 66 (1). pp. 51-64. ISSN 1381-5148

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Abstract

The synthesis of 3-, 5- and 8-arm dimethylaminoethyl methacrylate star polymers are reported, final M. (PDI) = 12.2 K (1.09), 18.9K (1. 10) and 38.4 K (1. 11), respectively. The synthesis of 3-arm methyl methacrylate and dimethylaminoethyl methacrylate block co-polymer stars is also described. Living polymerisation occurred in all cases providing well defined stars with predictable molecular weights and narrow polydispersity. A fluorescent tag, 2-(8-methacryloyloy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoquinoline-1,3-dione, derived from a commercially available pigment, was incorporated into the star polymers. The fluorescence spectra of the polymers prepared were recorded over a range of pH and the peak emission frequency and intensity have been reported, lambda(ex) = 462 nm. All of the multi-arm polymers exhibit fluorescence across a broad pH range with maximum emission at pH 4. A 3-arm star polymer has been demonstrated to show good bioadhesion in rat tissue. A reduced adhesion in epithelial tissues not covered by a viscoelastic mucus gel indicates an increased tendency for mucoadhesion over bioadhesion. (c) 2005 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology
Journal or Publication Title:	REACTIVE & FUNCTIONAL POLYMERS
Publisher:	ELSEVIER SCIENCE BV
ISSN:	1381-5148
Date:	January 2006
Volume:	66
Number:	1
Number of Pages:	14
Page Range:	pp. 51-64
Identification Number:	10.1016/j.reactfunctpolym.2005.07.024
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/34035

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