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Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice

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Isken, Frank, Klaus, Susanne, Osterhoff, Martin, Pfeiffer, Andreas F. H. and Weickert, Martin O. (2010) Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice. Journal of Nutritional Biochemistry, The, Vol.21 (No.4). pp. 278-284. ISSN 0955-2863

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Official URL: http://dx.doi.org/10.1016/j.jnutbio.2008.12.012

Abstract

Although most of the proposed beneficial effects of fiber consumption have been attributed to viscous and gel-forming properties of soluble fiber, it is mainly insoluble cereal fiber and whole grains that are strongly associated with reduced diabetes risk in prospective cohort studies, indicating that other unknown mechanisms are likely to be involved.

We performed a long-term study investigating potential protective effects of adding soluble guar fiber (10% w/w) vs. insoluble cereal fiber (10% w/w) to an isoenergetic and macronutrient matched high-fat diet in obesity-prone C57BL/6J mice. After 45 weeks, mice fed soluble vs. insoluble fiber showed both significantly increased body weight (41.8±3.0 vs. 33.6±1.5 g, P=.03) and elevated markers of insulin resistance. In mice fed soluble fiber, energy loss via the feces was significantly lower and colonic fermentation with production of short chain fatty acids (SCFA) was markedly increased. Gene expression analysis in white adipose tissue showed significantly increased levels of the fatty acid target G-protein coupled receptor-40 in soluble fiber-fed mice. Liver gene expression in the insoluble fiber group showed a pattern consistent with increased fatty acid oxidation. The present results show that soluble vs insoluble dietary fiber added to a high-fat, Western-style diet differently affected body weight and estimates of insulin sensitivity in obesity-prone mice. Soluble fiber intake with increased SCFA production significantly contributed to digested energy, thereby potentially outweighing the well known short-term beneficial effects of soluble fiber consumption.

Item Type:

Submitted Journal Article

Alternative Title:

Dietary fiber and obesity

Subjects:

Q Science > QL Zoology

Divisions:

Faculty of Medicine > Warwick Medical School

Library of Congress Subject Headings (LCSH):

Mice -- Health, Mice -- Food, Obesity, Fiber in human nutrition

Journal or Publication Title:

Journal of Nutritional Biochemistry, The

Publisher:

Elsevier Inc.

ISSN:

0955-2863

Official Date:

April 2010

Dates:

Date	Event
April 2010	Published

Volume:

Vol.21

Number:

No.4

Page Range:

pp. 278-284

Identification Number:

10.1016/j.jnutbio.2008.12.012

Status:

Peer Reviewed

Access rights to Published version:

Open Access

References:

[1] Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007;167:956-965
[2] de Munter JS, Hu FB, Spiegelman D, Franz M, van Dam RM Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med 2007;4:e261
[3] Weickert MO, Pfeiffer AF Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr 2008;138:439-442
[4] King DE, Egan BM, Woolson RF, Mainous AG, 3rd, Al-Solaiman Y, Jesri A Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level. Arch Intern Med 2007;167:502-506
[5] Howarth NC, Saltzman E, Roberts SB Dietary fiber and weight regulation. Nutr Rev 2001;59:129-139
[6] Pereira MA, Jacobs DR, Jr., Pins JJ, et al. Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 2002;75:848-855
[7] Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr 2005;82:559-567
[8] Weickert MO, Mohlig M, Schofl C, et al. Cereal fiber improves whole-body insulin sensitivity in overweight and obese women. Diabetes Care 2006;29:775-780
[9] Liese AD, Schulz M, Fang F, et al. Dietary glycemic index and glycemic load, carbohydrate and fiber intake, and measures of insulin sensitivity, secretion, and adiposity in the Insulin Resistance Atherosclerosis Study. Diabetes Care 2005;28:2832-2838
[10] Jenkins DJ, Kendall CW, Augustin LS, et al. Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes. Diabetes Care 2002;25:1522-1528
[11] Cameron-Smith D, Habito R, Barnett M, Collier GR Dietary guar gum improves insulin sensitivity in streptozotocin-induced diabetic rats. J Nutr 1997;127:359-364
[12] Song YJ, Sawamura M, Ikeda K, Igawa S, Yamori Y Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 2000;27:41-45
[13] Track NS, Cawkwell ME, Chin BC, Chiu SS, Haberer SA, Honey CR Guar gum consumption in adolescent and adult rats: short- and long-term metabolic effects. Can J Physiol Pharmacol 1985;63:1113-1121
[14] Weickert MO, Mohlig M, Koebnick C, et al. Impact of cereal fibre on glucose-regulating factors. Diabetologia 2005;48:2343-2353
[15] Weickert MO, Spranger J, Holst JJ, et al. Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety. Br J Nutr 2006;96:795-798
[16] Isken F, Schulz TJ, Mohlig M, Pfeiffer AF, Ristow M Chemical inhibition of citrate metabolism alters glucose metabolism in mice. Horm Metab Res 2006;38:543-545
[17] Ristow M, Mulder H, Pomplun D, et al. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J Clin Invest 2003;112:527-534
[18] Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing. Biochem Soc Trans 2006;34:770-773
[19] Stewart G, Hira T, Higgins A, Smith CP, McLaughlin JT Mouse GPR40 heterologously expressed in Xenopus oocytes is activated by short-, medium-, and long-chain fatty acids. Am J Physiol Cell Physiol 2006;290:C785-792
[20] Hong YH, Nishimura Y, Hishikawa D, et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology 2005;146:5092-5099
[21] Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest 2003;112:345-356
[22] Jenkins DJ, Kendall CW, Axelsen M, Augustin LS, Vuksan V Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 2000;11:49-56
[23] McNeil NI The contribution of the large intestine to energy supplies in man. Am J Clin Nutr 1984;39:338-342
[24] Backhed F, Manchester JK, Semenkovich CF, Gordon JI Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 2007;104:979-984
[25] Thorburn A, Muir J, Proietto J Carbohydrate fermentation decreases hepatic glucose output in healthy subjects. Metabolism 1993;42:780-785
[26] Galisteo M, Duarte J, Zarzuelo A Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J Nutr Biochem 2008;19:71-84
[27] Robertson MD, Currie JM, Morgan LM, Jewell DP, Frayn KN Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects. Diabetologia 2003;46:659-665
[28] Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 2005;1:245-258
[29] Wolfrum C, Stoffel M Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab 2006;3:99-110
[30] Pittler MH, Ernst E Guar gum for body weight reduction: meta-analysis of randomized trials. Am J Med 2001;110:724-730