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A serological investigation of caseous lymphadenitis in four flocks of sheep
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Malone, Frank (Frank E.), Fee, Seán A., Kamp, Elbarte M., King, David C., Baird, Graham J., O'Reilly, Kath M. and Murdock, Fiona E. A.. (2006) A serological investigation of caseous lymphadenitis in four flocks of sheep. Irish Veterinary Journal, Vol.59 (No.1). pp. 19-21. ISSN 0368-0762
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Official URL: http://dx.doi.org/10.1186/2046-0481-59-1-19
Abstract
A double antibody sandwich ELISA developed by ID-DLO, Lelystad to detect Corynebocterium pseudotuberculosis infection was used on 329 sheep from four pedigree Suffolk flocks in which clinical cases of caseous lymphadenitis (CLA) had occurred. At subsequent necropsy, typical CLA lesions were seen in 133 sheep, and the diagnosis was confirmed on culture. Lesions were most commonly seen in lungs (n = 46), parotid lymph nodes (n = 44), prescapular lymph nodes (n = 38) and mediastinal lymph nodes (n = 31). The sensitivity of the ELISA test for detecting culture-positive sheep was 0.88, while the specificity of the test was 0.55. The antibody ELISA detected 87.5 per cent of sheep that had CLA lesions restricted to internal organs only. It was concluded that the ELISA test has a valuable role in detecting sheep with both clinical and subclinical CLA.
| Item Type: | Journal Article |
|---|---|
| Subjects: | S Agriculture > SF Animal culture |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) |
| Library of Congress Subject Headings (LCSH): | Corynebacterium pseudotuberculosis, Pseudotuberculosis, Veterinary serology, Sheep -- England -- Suffolk |
| Journal or Publication Title: | Irish Veterinary Journal |
| Publisher: | Veterinary Ireland |
| ISSN: | 0368-0762 |
| Date: | January 2006 |
| Volume: | Vol.59 |
| Number: | No.1 |
| Number of Pages: | 3 |
| Page Range: | pp. 19-21 |
| Identification Number: | 10.1186/2046-0481-59-1-19 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access |
| References: | Baird, G.J. (2003). Current perspectives on caseous lymphadenitis. In Practice 25: 62-68. Batey, R.G. (1986). Pathogenesis of caseous lymphadenitis in sheep and goats. Australian Veterinary Journal 63: 269-272. Brown, C.C. and Olander, H.J. (1987). Caseous lymphadenitis of goats and sheep: a review. Veterinary Bulletin 57: 1-12. Cowan, S.T. and Steel, K.J. (1974). Cowan and Steel’s Manual for the Identification of Medical Bacteria. Second Edition. Cambridge: Cambridge University Press. Dercksen, D.P., Brinkhof, J.M.A., Dekker-Norren, T., van Maanen, K., Bode, C.F., Baird, G. and Kamp, E.M. (2000). A comparison of four serological tests for the diagnosis of caseous lymphadenitis in sheep and goats. Veterinary Microbiology 75: 167-175. |
| URI: | http://wrap.warwick.ac.uk/id/eprint/34046 |
Data sourced from Thomson Reuters' Web of Knowledge
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