UNSPECIFIED (2006) Molecular analysis of respiratory syncytial virus reinfections in infants from coastal Kenya. In: Conference of the Royal-Society-of-Tropical-Medicine-and Hygiene, Liverpool Sch Tropical Med, Liverpool, ENGLAND, NOV 18, 2004. Published in: JOURNAL OF INFECTIOUS DISEASES, 193 (1). pp. 59-67. ISSN 0022-1899.

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Abstract

Background. Individuals are reinfected with respiratory syncytial virus (RSV) repeatedly. The nature of reinfection, in relation to RSV genetic and antigenic diversity, is ill defined and has implications for persistence and vaccine control.

Methods. We examined the molecular relatedness of RSV causing primary and repeat infections, by phylogenetic analysis of the attachment (G) gene in 12 infants from a birth cohort in rural Kenya, using nasal wash samples collected during a 16-month period in 2002-2003, which spanned 2 successive epidemics.

Results. Six infants were infected during both epidemics, 4 with RSV-A in the first epidemic followed by RSV-B during the second epidemic and 2 with RSV-A during both epidemics, with no significant G gene sequence variability between samples. Two infants were infected and reinfected with different RSV-A strains during the same epidemic. Possible viral persistence was suspected in the remaining 4 infants, although reinfection with the same variant cannot be excluded.

Conclusions. These are the first data that specifically address strain-specific reinfections in infancy in relation to the primary infecting variant. The data strongly suggest that, following primary infection, some infants lose strain-specific immunity within 7-9 months (between epidemics) and group-specific immunity within 2-4 months (during an epidemic period).

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology > QR355 Virology Q Science > QR Microbiology
Journal or Publication Title:	JOURNAL OF INFECTIOUS DISEASES
Publisher:	UNIV CHICAGO PRESS
ISSN:	0022-1899
Official Date:	1 January 2006
Dates:	Date Event 1 January 2006 UNSPECIFIED
Volume:	193
Number:	1
Number of Pages:	9
Page Range:	pp. 59-67
Publication Status:	Published
Title of Event:	Conference of the Royal-Society-of-Tropical-Medicine-and Hygiene
Location of Event:	Liverpool Sch Tropical Med, Liverpool, ENGLAND
Date(s) of Event:	NOV 18, 2004

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