UNSPECIFIED. (2005) Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. JOURNAL OF CELL SCIENCE, 118 (22). pp. 5279-5289. ISSN 0021-9533

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Abstract

Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these Dvl-2-containing structures correspond to intracellular vesicles and may be involved in the Wnt signal transduction process. We report that cytoplasmic puncta are primarily formed in cells expressing Dvl-2 at high levels. Lower levels of expression can activate signalling without forming puncta. The structures do not localise with markers of the early or late endocytic pathway and time-lapse analysis demonstrates that Dvl-2 puncta move in a random fashion over short distances but do not originate from the plasma membrane. Based on our findings, we propose that Dvl-2 puncta are protein aggregates that are not required for signalling.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	JOURNAL OF CELL SCIENCE
Publisher:	COMPANY OF BIOLOGISTS LTD
ISSN:	0021-9533
Date:	15 November 2005
Volume:	118
Number:	22
Number of Pages:	11
Page Range:	pp. 5279-5289
Identification Number:	10.1242/jcs.02647
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/34224

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