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Evidence for the unusual condensation of a diketide with a pentulose in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2)
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Corre, Christophe and Challis, Gregory L. (2005) Evidence for the unusual condensation of a diketide with a pentulose in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2). Chembiochem, Volume 6 (Number 12). pp. 2166-2170. doi:10.1002/cbic.200500243 ISSN 1439-4227.
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Official URL: http://dx.doi.org/10.1002/cbic.200500243
Abstract
How is the extraordinarily dense array of functional groups adorning the cyclopentane rings of the antibiotic methylenomycins assembled? Here it is shown that the northern 5 carbons of the methylenomycins (blue) derive from a pent(ul)ose intermediate of the pentose phosphate pathway. Together with previous results showing that the southern 4 carbons (green) derive from two acetate units and analysis of the mmy gene cluster that directs methylenomycin biosynthesis in Streptomyces coelicolor A3(2), these results suggest plausible early steps for methylenomycin biosynthesis via a butenolide intermediate.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Journal or Publication Title: | Chembiochem | ||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
| ISSN: | 1439-4227 | ||||
| Official Date: | December 2005 | ||||
| Dates: |
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| Volume: | Volume 6 | ||||
| Number: | Number 12 | ||||
| Number of Pages: | 5 | ||||
| Page Range: | pp. 2166-2170 | ||||
| DOI: | 10.1002/cbic.200500243 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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