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The tumor kinetics of multiple myeloma following autologous stem cell transplantation as assessed by measuring serum-free light chains
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UNSPECIFIED. (2006) The tumor kinetics of multiple myeloma following autologous stem cell transplantation as assessed by measuring serum-free light chains. LEUKEMIA & LYMPHOMA, 47 (1). pp. 21-28. ISSN 1042-8194
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Official URL: http://dx.doi.org/10.1080/10428190500254216
Abstract
In multiple myeloma, changes in serum-free immunoglobulin light chains (FLC) are a more rapid indicator of treatment response than intact immunoglobulin due to their shorter serum half-life. The present study analysed the changes in serum FLC after autologous peripheral blood stem cell transplantation (PBSCT) in 19 patients. The majority of myeloma patients (18 of 19) undergoing PBSCT had a rapid fall in FLC concentrations. In all 11 of 19 patients with raised tumor FLC, it fell within 48 h following high-dose melphalan. In patients with monoclonal intact immunoglobulin, the tumor FLC fell quicker (median half-life 4.3 days) than the monoclonal intact immunoglobulin (median half-life 14 days). FLC recovery occurred after (13 of 19) or around the time of neutrophil engraftment (6 of 19). With a median follow up of 220 days post-transplant, 16 of 19 patients have a normal FLC ratio and 3 of 19 have an elevated tumor FLC/abnormal ratio. FLC assays provided a sensitive monitor of changes in tumor and non-tumor plasma cells after PBSCT. This assay is potentially valuable as a marker of chemosensitivity, as an indicator of residual tumor and indicated time to lymphocyte engraftment. Further follow-up is required to ascertain whether differences in the kinetics of FLC responses have any prognostic clinical utility.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RB Pathology |
| Journal or Publication Title: | LEUKEMIA & LYMPHOMA |
| Publisher: | TAYLOR & FRANCIS LTD |
| ISSN: | 1042-8194 |
| Date: | January 2006 |
| Volume: | 47 |
| Number: | 1 |
| Number of Pages: | 8 |
| Page Range: | pp. 21-28 |
| Identification Number: | 10.1080/10428190500254216 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/34259 |
Data sourced from Thomson Reuters' Web of Knowledge
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