The Library
Cognitive function in healthy older European adults : the ZENITH study
Tools
Simpson, E. E. A., Maylor, Elizabeth A., Rae, G., Meunier, N., Andriollo-Sanchez, M., Catasta, G., McConville, C., Ferry, M., Polito, A., Stewart-Knox, B. J., Secker, D. L. and Coudray, C.. (2005) Cognitive function in healthy older European adults : the ZENITH study. European Journal of Clinical Nutrition, Vol.59 (Suppl. 2). S26-S30. ISSN 0954-3007
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/sj.ejcn.1602294
Abstract
Objective: Baseline data are reported from a study of the effects of zinc supplementation on cognitive function in older adults as assessed by the CANTAB computerised test battery. Design: This is a multicentre prospective intervention study employing a randomised double-blind design. Setting: European community-based study. Participants: There are 387 healthy adults aged 55-87 y from centres in France, Italy and Northern Ireland. Interventions: Measures of visual memory, working memory and attention were obtained at baseline (prior to supplementation). Results: Younger adults (< 70 y) performed significantly better than older adults (> 70 y) on all tests, with minimal differences between centres. In addition, men outperformed women on tests of spatial span, pattern recognition memory and reaction times, although these gender differences varied somewhat between centres. Conclusions: The results are generally consistent with previous age- and gender-related effects on cognitive functioning.
| Item Type: | Journal Article |
|---|---|
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Science > Psychology |
| Library of Congress Subject Headings (LCSH): | Cognition — Age factors , Cognition in old age , Zinc deficiency diseases, Zinc — Physiological effect , Diet, Nutrition surveys |
| Journal or Publication Title: | European Journal of Clinical Nutrition |
| Publisher: | Nature Publishing Group |
| ISSN: | 0954-3007 |
| Date: | November 2005 |
| Volume: | Vol.59 |
| Number: | Suppl. 2 |
| Number of Pages: | 5 |
| Page Range: | S26-S30 |
| Identification Number: | 10.1038/sj.ejcn.1602294 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | European Commission (EC) |
| Grant number: | QLK1-CT-2001-00168 (EC) |
| References: | Bentley ME, Caulfield LE, Ram M, Santizo MC, Hurtado E, Rivera JA, Ruel MT & Brown KH (1997): Zinc supplementation affects the activity patterns of rural Guatemalan infants. J. Nutr. 127, 1333–1338. Chari G, Shaw PJ & Sahgal A (1996): Nonverbal visual attention, but not recognition memory or learning, processes are impaired in motor neurone disease. Neuropsychologia 34, 377–385. Coull JT, Frith CD, Frackowiak RSJ & Grasby PM (1996): A frontoparietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neuropsychologia 34, 1085–1095. Crawford IL (1983): Zinc in the hippocampus. In Neurobiology of the Trace Elements, Vol 1, eds IE Dreosti & RM Smith, pp 163–211. New Jersey: Humana Press. Cuajungco MP & Faget KY (2003): Zinc takes the centre stage: its paradoxical role in Alzheimer’s disease. Brain Res. Rev. 41, 44–56. De Luca CR, Wood SJ, Anderson V, Buchanan J, Proffitt TM, Mahony K & Pantelis C (2003): Normative data from the Cantab. I: development of executive function over the lifespan. J. Clin. Exp. Neuropsychol. 25, 242–254. Elliott R & Sahakian BJ (1995): The neuropsychology of schizophrenia: relations with clinical and neurobiological dimensions. Psychol. Med. 25, 581–594. Fernstrom JD (2000): Can nutrient supplements modify brain function? Am. J. Clin. Nutr. 71, 1669S–1673S. Folstein MF, Folstein SE & McHugh PR (1975): Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189–198. Gilbride JA, Amella EJ, Breines EB, Mariano C & Mezey M (1998): Nutrition and health status assessment of community residing elderly in New York City: a pilot study. J. Am. Diet Assoc. 95, 554–558. Goldman-Rakic PS (1987): Circuitry of primate prefrontal cortex and the regulation of behaviour by representational memory. In Handbook of Physiology: The Nervous System, Higher Functions of the Brain, Vol 5, Part 1, eds F Plum & V Mountcastle, pp 373–417. Bethseda, MD: American Physiological Society. Huang EP (1997): Metal ions and synaptic transmission: think zinc. Pract. Nat. Acad. Sci. USA 94, 13386–13387. Kimura D (1963): Right temporal lobe damage. Arch. Neurol. 8, 264–271. Kolb B & Stewart J (1991): Sex-related differences in dendritic branching of cells in the prefrontal cortex of rats. J. Neuroendocrinol. 3, 95–99. Kretsch MJ, Fong AKH, Penland JG, Sutherland B & King JC (1999): Cognitive effects of adaptation to a low zinc diet in healthy men. In 10th Anniversary Symposium on Trace Elements in Man and Animal, 999–1001, eds AM Rousell, RA Anderson & AE Favier. New York: Kluwer Academic/Plenum Publishers. Laslett P (1997): Interpreting the demographic changes. Philos. Trans. R. Soc. London B 352, 1805–1809. Louis WJ, Mander AG, Dawson M, O’Callaghan C & Conway EL (1999): Use of computerized neuropsychological tests (CANTAB) to assess cognitive effects of antihyptertensive drugs in the elderly. J. Hyperten. 17, 1813–1819. Cognition in older Europeans EEA Simpson et al S29 European Journal of Clinical Nutrition Luciana M & Nelson CA (2002): Assessment of neuropsychological function through use of the Cambridge Neuropsychological Testing Automated Battery: Performance in 4- to 12-year-old children. Dev. Neuropsychol. 22, 595–624. McDaniel MA, Maier SF & Einstein GO (2002): ‘Brain-specific’ nutrients: a memory cure? Psychol. Sci. Publ. Interest 3, 12–38. Meinz EJ & Salthouse TA (1998): Is age kinder to females than to males? Psychonomic Bull. Rev. 5, 56–70. Mishkin M (1982): A memory system in the monkey. Philos. Trans. R. Soc. London 298, 85–95. Nettelbeck T & Rabbitt PMA (1992): Ageing, cognitive performance and mental speed. Intelligence 16, 189–205. Ortega RM, Requejo AM, Andres P, Lopez-Sobaler AM, Quintas ME, Redondo MR, Navia B & Rivas T (1997): Dietary intake and cognitive function in a group of elderly people. Am. J. Clin. Nutr. 66, 803–809. Owen AM, Iddon JL, Hodges JR, Summers BA & Robbins TW (1997): Spatial and non-spatial working memory at different stages of Parkinson’s disease. Neuropsychologia 35, 519–532. Owen AM, Morris RG, Sahakian BJ, Polkey CE & Robbin TW (1996): Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Brain 119, 1597–1615. Owen AM, Sahakian BJ, Semple J, Polkey CE & Robbins TW (1995): Visuo-spatial short term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalohippocampectomy in man. Neuropsychologia 33, 1–24. Petrides M & Milner B (1982): Deficits on subject ordered tasks after frontal and temporal lobe lesions in man. Neuropsychologia 20, 249–262. Pfeiffer E (1975): A short portable questionnaire for the assessment of organic brain deficit in elderly patients. J. Am. Geriatr. Soc. 23, 433–439. Piggott S & Milner B (1993): Memory for different aspects of visual scenes after unilateral temporal or frontal lobe resection. Neuropsychologia 31, 1–15. Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L & Rabbitt PM (1994): The Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytical study in a large sample of normal elderly volunteers. Dementia 5, 266–281. Sahakian BJ & Owen AM (1992): Computerised assessment in neuropsychiatry using CANTAB. J. R. Soc. Med. 85, 399–402. Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, Crayton L, Crockford HA, Crooks M, Hill K & Levy R (1990): Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer’s disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology 110, 395–401. Sandstead HH, Penland JG, Alcock NW, Dayal HH, Chen XC, Li JS, Zhoa F & Yang JJ (1998): Effects of repletion with zinc and other micronutrients on neurpsychologic performance and growth of Chinese children. Am. J. Clin. Nutr. 68, 470S–475S. Sazawal S, Bentley M, Black RE, Dhingra P, George S & Bhan MK (1996): Effects of zinc supplementation on observed activity in low socio-economic Indian preschool children. Pediatrics 98, 1132–1137. Takeda A (2000): Movement of zinc and its functional significance in the brain. Brain Res. Rev. 34, 137–148. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M & Leirer VO (1983): Development and validation of a geriatric depression screening scale: a preliminary report. J. Psychiat. Res. 17, 37–49. |
| URI: | http://wrap.warwick.ac.uk/id/eprint/34338 |
Data sourced from Thomson Reuters' Web of Knowledge
Actions (login required)
![]() |
View Item |
Tools
Tools

