UNSPECIFIED (2005) Neuronal homeostasis through translational control. MOLECULAR NEUROBIOLOGY, 32 (2). pp. 113-121. ISSN 0893-7648

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Abstract

Translational repression is a key component of the mechanism that establishes segment polarity during early embryonic development in the fruitfly Drosophila melanogaster. Two proteins, Pumilio (Pum) and Nanos, block the translation of hunchback messenger RNA in only the posterior segments, thereby promoting an abdominal fate. More recent studies focusing on postembryonic neuronal function have shown that Pum is also integral to numerous mechanisms that allow neurons to adapt to the changing requirements placed on them in a dynamic nervous system. These mechanisms include those contributing to dendritic structure, synaptic growth, neuronal excitability, and formation of long-term memory. This article describes these new studies and highlights the role of translational repression in regulation of neuronal processes that compensate for change.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title:	MOLECULAR NEUROBIOLOGY
Publisher:	HUMANA PRESS INC
ISSN:	0893-7648
Date:	October 2005
Volume:	32
Number:	2
Number of Pages:	9
Page Range:	pp. 113-121
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/34435

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