Duprey, Jean-Louis, Bassani, Dario, Hyde, Eva, Ludwig, Christian, Rodger, Alison, Vyle, Joseph, Wilkie, John, Zhao, Zheng-Yun and Tucker, James (2011) Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors : discrimination between various base-pair mismatches. Supramolecular Chemistry, Vol.23 (No.3-4). pp. 273-277. doi:10.1080/10610278.2010.523117 ISSN 1061-0278.

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Abstract

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Anthracene, Fluorimetry, Fluorescent probes, DNA, Nucleotide sequence, Oligonucleotides
Journal or Publication Title:	Supramolecular Chemistry
Publisher:	Taylor & Francis Ltd.
ISSN:	1061-0278
Official Date:	2011
Dates:	Date Event 2011 Published
Volume:	Vol.23
Number:	No.3-4
Page Range:	pp. 273-277
DOI:	10.1080/10610278.2010.523117
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	University of Birmingham, Engineering and Physical Sciences Research Council (EPSRC), Advantage West Midlands

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