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Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors : discrimination between various base-pair mismatches
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Duprey, Jean-Louis, Bassani, Dario, Hyde, Eva, Ludwig, Christian, Rodger, Alison, Vyle, Joseph, Wilkie, John, Zhao, Zheng-Yun and Tucker, James. (2011) Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors : discrimination between various base-pair mismatches. Supramolecular Chemistry, Vol.23 (No.3-4). pp. 273-277. ISSN 1061-0278
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Official URL: http://dx.doi.org/10.1080/10610278.2010.523117
Abstract
A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Anthracene, Fluorimetry, Fluorescent probes, DNA, Nucleotide sequence, Oligonucleotides |
| Journal or Publication Title: | Supramolecular Chemistry |
| Publisher: | Taylor & Francis Ltd. |
| ISSN: | 1061-0278 |
| Date: | 2011 |
| Volume: | Vol.23 |
| Number: | No.3-4 |
| Page Range: | pp. 273-277 |
| Identification Number: | 10.1080/10610278.2010.523117 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | University of Birmingham, Engineering and Physical Sciences Research Council (EPSRC), Advantage West Midlands |
| URI: | http://wrap.warwick.ac.uk/id/eprint/34656 |
Data sourced from Thomson Reuters' Web of Knowledge
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