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Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors : discrimination between various base-pair mismatches
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Duprey, Jean-Louis, Bassani, Dario, Hyde, Eva, Ludwig, Christian, Rodger, Alison, Vyle, Joseph, Wilkie, John, Zhao, Zheng-Yun and Tucker, James (2011) Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors : discrimination between various base-pair mismatches. Supramolecular Chemistry, Vol.23 (No.3-4). pp. 273-277. doi:10.1080/10610278.2010.523117 ISSN 1061-0278.
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Official URL: http://dx.doi.org/10.1080/10610278.2010.523117
Abstract
A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Anthracene, Fluorimetry, Fluorescent probes, DNA, Nucleotide sequence, Oligonucleotides | ||||
Journal or Publication Title: | Supramolecular Chemistry | ||||
Publisher: | Taylor & Francis Ltd. | ||||
ISSN: | 1061-0278 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol.23 | ||||
Number: | No.3-4 | ||||
Page Range: | pp. 273-277 | ||||
DOI: | 10.1080/10610278.2010.523117 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | University of Birmingham, Engineering and Physical Sciences Research Council (EPSRC), Advantage West Midlands |
Data sourced from Thomson Reuters' Web of Knowledge
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