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Prediction of photoperiodic regulators from quantitative gene circuit models

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Salazar, Jose Domingo, Saithong, Treenut, Brown, Paul E., Foreman, Julia, Locke, James C. W., Halliday, Karen J., Carré, Isabelle A., Rand, D. A. (David A.) and Millar, A. J. (Andrew J.). (2009) Prediction of photoperiodic regulators from quantitative gene circuit models. Cell, Vol.139 (No.6). pp. 1170-1179. ISSN 1097-4172

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Official URL: http://dx.doi.org/10.1016/j.cell.2009.11.029

Abstract

Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm. Sufficient data are available to test this quantitatively in plants, though not yet in animals. In Arabidopsis, the clock-regulated genes CONSTANS (CO) and FLAVIN, KELCH, F-BOX (FKF1) and their lightsensitive proteins are thought to form an external coincidence sensor. We use 40 timeseries of molecular data to model the integration of light and timing information by CO, its target gene FLOWERING LOCUS T (FT), and the circadian clock. Among other predictions, the models show that FKF1 activates FT. We demonstrate experimentally that this effect is independent of the known activation of CO by FKF1, thus we locate a major, novel controller of photoperiodism. External coincidence is part of a complex photoperiod sensor: modelling makes this complexity explicit and may thus contribute to crop improvement.

Item Type:	Journal Article
Subjects:	Q Science > QK Botany
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Mathematics Faculty of Science > Physics Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH):	Arabidopsis thaliana -- Genetics, Circadian rhythms -- Mathematical models, Plant photoperiodism -- Mathematical models
Journal or Publication Title:	Cell
Publisher:	Elsevier
ISSN:	1097-4172
Date:	11 December 2009
Volume:	Vol.139
Number:	No.6
Number of Pages:	10
Page Range:	pp. 1170-1179
Identification Number:	10.1016/j.cell.2009.11.029
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Gatsby Charitable Foundation (GCF), Thailand, European Union (EU)
Grant number:	BEP17427 (BBSRC), F0052371 (BBSRC/EPSRC), 005137 (EU), D019621 (EPSRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/34801