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Prediction of photoperiodic regulators from quantitative gene circuit models
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Salazar, Jose Domingo, Saithong, Treenut, Brown, Paul E., Foreman, Julia, Locke, James C. W., Halliday, Karen J., Carré, Isabelle A., Rand, D. A. (David A.) and Millar, A. J. (Andrew J.) (2009) Prediction of photoperiodic regulators from quantitative gene circuit models. Cell, Vol.139 (No.6). pp. 1170-1179. doi:10.1016/j.cell.2009.11.029 ISSN 1097-4172.
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Official URL: http://dx.doi.org/10.1016/j.cell.2009.11.029
Abstract
Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm. Sufficient data are available to test this quantitatively in plants, though not yet in animals. In Arabidopsis, the clock-regulated genes CONSTANS (CO) and FLAVIN, KELCH, F-BOX (FKF1) and their lightsensitive proteins are thought to form an external coincidence sensor. We use 40 timeseries of molecular data to model the integration of light and timing information by CO, its target gene FLOWERING LOCUS T (FT), and the circadian clock. Among other predictions, the models show that FKF1 activates FT. We demonstrate experimentally that this effect is independent of the known activation of CO by FKF1, thus we locate a major, novel controller of photoperiodism. External coincidence is part of a complex photoperiod sensor: modelling makes this complexity explicit and may thus contribute to crop improvement.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QK Botany | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Library of Congress Subject Headings (LCSH): | Arabidopsis thaliana -- Genetics, Circadian rhythms -- Mathematical models, Plant photoperiodism -- Mathematical models | ||||
| Journal or Publication Title: | Cell | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 1097-4172 | ||||
| Official Date: | 11 December 2009 | ||||
| Dates: |
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| Volume: | Vol.139 | ||||
| Number: | No.6 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 1170-1179 | ||||
| DOI: | 10.1016/j.cell.2009.11.029 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Date of first compliant deposit: | 16 December 2015 | ||||
| Date of first compliant Open Access: | 16 December 2015 | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Gatsby Charitable Foundation (GCF), Thailand, European Union (EU) | ||||
| Grant number: | BEP17427 (BBSRC), F0052371 (BBSRC/EPSRC), 005137 (EU), D019621 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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