Modelling health scores with the skew-normal distribution
Hutton, Jane (Statistician) and Stanghellini, E. (2009) Modelling health scores with the skew-normal distribution. Working Paper. Coventry: University of Warwick. Centre for Research in Statistical Methodology. Working papers, Vol.2009 (No.39).
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Official URL: http://www2.warwick.ac.uk/fac/sci/statistics/crism...
Health care interventions which use quality of life or health scores often provide data
which are skewed and bounded. The scores are typically formed by adding up responses
to a number of questions. Different questions might have different weights, but the scores
will be bounded, and are often scaled to the range 0 to 100. If improvement in health
over time is measured, scores will tend to cluster near the 'healthy' or 'good' boundary
as time progresses, leading to a skew distribution. Further, some patients will drop out
as time progresses, so the scores reflect a selected population.
We fit models based on the skew-normal distribution to data from a randomised controlled trial of treatments for sprained ankles, in which scores were recorded at baseline
and 1, 3 and 9 months. We consider the extent to which skewness in the data can be
explained by the clustering at the boundary via a comparison between a censored normal
and a censored skew-normal model.
As this analysis is based on the complete data only, a formula for the distortion of
the treatment effects due to informative drop-out is given. This allows us to assess under
which conditions the conclusions drawn on the complete data may be either reinforced or
reversed, when the informative drop-out process is taken into account.
|Item Type:||Working or Discussion Paper (Working Paper)|
|Subjects:||Q Science > QA Mathematics|
|Divisions:||Faculty of Science > Statistics|
|Library of Congress Subject Headings (LCSH):||Medical care -- Statistics|
|Series Name:||Working papers|
|Publisher:||University of Warwick. Centre for Research in Statistical Methodology|
|Place of Publication:||Coventry|
|Number of Pages:||13|
|Status:||Not Peer Reviewed|
|Access rights to Published version:||Open Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), Great Britain. Dept. of Health (DoH), University of Warwick. Centre for Research in Statistical Methodology, Italy. Ministero dell'istruzione, dell'università e della ricerca (MIUR)|
|Grant number:||01/14/10 (DoH), PRIN 2007XECZ7L−003 (MIUR)|
 Azzalini A, Capitanio A. Statistical application of the multivariate skew-normal distribution.
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