Defective interfering virus protects elderly mice from influenza
Scott, P. D. (Paul D.), Meng, Bo, Marriott, Anthony C., Easton, A. J. (Andrew J.) and Dimmock, N. J.. (2011) Defective interfering virus protects elderly mice from influenza. Virology Journal, Vol.8 (No.212). ISSN 1743-422X
WRAP_Dimmock_1743-422X-8-212.pdf - Published Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1186/1743-422X-8-212
Background: We have identified and characterised a defective-interfering (DI) influenza A virus particles containing
a highly deleted segment 1 RNA that has broad-spectrum antiviral activity. In young adult mice it exerts protection
against several different subtypes of influenza A virus (defined here as homologous or genetically compatible
protection) and against a paramyxovirus and an influenza B virus (heterologous or genetically unrelated
protection). Homologous protection is mediated by replication competition between the deleted and full-length
genomes, and heterologous protection occurs through stimulation of innate immunity, especially interferon type I.
Methods: A single dose of the protective DI virus was administered intranasally to elderly mice at -7, -1 and +1
days relative to intranasal challenge with influenza A virus.
Results: A single dose of the DI virus given 1 or 7 days protected elderly mice, reducing a severe, sometimes fatal
disease to a subclinical or mild infection. In contrast, all members of control groups treated with inactivated DI
virus before challenge became extremely ill and most died. Despite the subclinical/mild nature of their infection,
protected mice developed solid immunity to a second infectious challenge.
Conclusions: The defective interfering virus is effective in preventing severe influenza A in elderly mice and may
offer a new approach to protection of the human population.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology > QR355 Virology|
|Divisions:||Faculty of Science > Life Sciences (2010- )|
|Library of Congress Subject Headings (LCSH):||Influenza -- Prevention, Influenza A virus, Antiviral agents|
|Journal or Publication Title:||Virology Journal|
|Publisher:||BioMed Central Ltd.|
|Official Date:||9 May 2011|
|Access rights to Published version:||Open Access|
|Funder:||Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC)|
1. Treanor JJ, Falsey A: Respiratory viral infections in the elderly. Antiviral
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