New organic and organometallic catalysts for asymmetric synthesis
Manville, Charles (2010) New organic and organometallic catalysts for asymmetric synthesis. PhD thesis, University of Warwick.Full text not available from this repository.
Official URL: http://webcat.warwick.ac.uk/record=b2491635~S15
Monodentate phosphorus ligands based on BINOL have been synthesised and
applied to metal catalysed pressure hydrogenation and conjugate addition.
Novel phosphorus containing enantioselective organocatalysts have been synthesised
from DPEN and proline, and studied in the Michael addition of acetone to trans-β-
nitrostyrenes, with up to 96 % e.e. The optimum reaction conditions for reaction rate
and enantioselectivity have been investigated. Related proline-DPEN coupled
organocatalysts have been synthesised and applied to the coupling reaction between
DEAD and aldehydes.
The proline-DPEN coupled compounds have been investigated for uses as ligands in
the ruthenium catalysed asymmetric transfer hydrogenation of ketones in an aqueous
medium. The hydrogenation reactions can be performed with good conversions and
up to 98% e.e.
|Item Type:||Thesis or Dissertation (PhD)|
|Subjects:||Q Science > QD Chemistry|
|Library of Congress Subject Headings (LCSH):||Asymmetric synthesis, Catalysts -- Synthesis, Ligands -- Synthesis, Organometallic compounds, Organic compounds|
|Official Date:||October 2010|
|Institution:||University of Warwick|
|Theses Department:||Department of Chemistry|
|Sponsors:||Engineering and Physical Sciences Research Council (EPSRC) ; Rhodia (Firm)|
|Extent:||xi, 207 leaves : ill.|
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