Thermodynamic capacity of a protein
Fink, Thomas M. A. and Ball, R. C. (2000) Thermodynamic capacity of a protein. Working Paper. Cornell University Library, Cornell.
WRAP_Ball_Thermodynamic_capacity.pdf - Submitted Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://arxiv.org/abs/cond-mat/0008474v1
We show that a protein can be trained to recognise multiple conformations, analogous to an associative memory, and provide capacity calculations based on energy fluctuations and information theory. Unlike the linear capacity of a Hopfield network, the number of conformations which can be remembered by a protein sequence depends on the size of the amino acid alphabet as ln A, independent of protein length. This admits the possibility of certain proteins, such as prions, evolving to fold to independent stable conformations, as well as novel possibilities for protein and heteropolymer design.
|Item Type:||Working or Discussion Paper (Working Paper)|
|Subjects:||Q Science > QC Physics|
|Divisions:||Faculty of Science > Physics|
|Library of Congress Subject Headings (LCSH):||Proteins -- Thermal properties|
|Publisher:||Cornell University Library|
|Place of Publication:||Cornell|
|Number of Pages:||5|
|Status:||Not Peer Reviewed|
|Access rights to Published version:||Open Access|
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