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Shape dependence of the neuronal response to alternating electrical fields
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Malik, Naveed A. and Richardson, Magnus J. E.. (2010) Shape dependence of the neuronal response to alternating electrical fields. BMC Neuroscience, Vol.11 (Suppl.1, no.P156). ISSN 1471-2202
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Official URL: http://dx.doi.org/10.1186/1471-2202-11-S1-P156
Abstract
Neuronal interactions with electric fields depend on the biophysical properties of the neuronal membrane as well as the geometry of the cell relative to the field vector. Biophysically detailed modeling of these spatial effects is central to understanding neuron-to-neuron electrical (ephaptic) interactions as well as how externally applied electrical fields, such as radio-frequency radiation from wireless devices or therapeutic Deep Brain Stimulation (DBS), interact with neurons. Here we examine in detail the shape-dependent response properties of cells in oscillating electrical fields by solving Maxwell’s equations for a geometrically extended neuron of various radii-to-length ratios.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Faculty of Science > Centre for Systems Biology |
| Library of Congress Subject Headings (LCSH): | Neurons -- Physiology, Electric fields |
| Journal or Publication Title: | BMC Neuroscience |
| Publisher: | BioMed Central Ltd. |
| ISSN: | 1471-2202 |
| Date: | 20 July 2010 |
| Volume: | Vol.11 |
| Number: | Suppl.1, no.P156 |
| Identification Number: | 10.1186/1471-2202-11-S1-P156 |
| Status: | Peer Reviewed |
| Access rights to Published version: | Open Access |
| References: | 1. Schwan HP: Biophysics of the interaction of electromagnetic energy with cells and membranes. In: Grandolfo M, Michaelson SM, Rindi A, editors. Biological effects and dosimetry of nonionising radiation. Plenum Press, New York 1983, 213-231. 2. Marszalek P, Liu D, Tsong TY: Schwan equation and transmembrane potential induced by alternating electric field. Biophys J 1990, 58:1053-1058. 3. Deans JK, Powell AD, Jefferys JGR: Sensitivity of coherent oscillations in rat hippocampus to AC electric fields. J Physiol 2007, 583:555-565. |
| URI: | http://wrap.warwick.ac.uk/id/eprint/36114 |
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