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Pharmacogenetics of ophthalmic topical β-blockers
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Sidjanin, Duska J., McCarty, Catherine A., Patchett, Richard, Smith, Edward M. and Wilke, Russell A. (2008) Pharmacogenetics of ophthalmic topical β-blockers. Personalized Medicine, Vol.5 (No.4). pp. 377-385. doi:10.2217/17410541.5.4.377 ISSN 1741-0541.
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Official URL: http://dx.doi.org/10.2217/17410541.5.4.377
Abstract
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure. Genetic variability has been postulated to contribute to interpersonal differences in efficacy and safety of topical β-blockers. This review summarizes clinically significant polymorphisms that have been identified in the β-adrenergic receptors (ADRB1, ADRB2 and ADRB3). The implications of polymorphisms in CYP2D6 are also discussed. Although the candidate-gene approach has facilitated significant progress in our understanding of the genetic basis of glaucoma treatment response, most drug responses involve a large number of genes, each containing multiple polymorphisms. Genome-wide association studies may yield a more comprehensive set of polymorphisms associated with glaucoma outcomes. An understanding of the genetic mechanisms associated with variability in individual responses to topical β-blockers may advance individualized treatment at a lower cost.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RE Ophthalmology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Glaucoma -- Genetic aspects, Adrenergic beta blockers, Beta adrenoceptors, Genetic polymorphisms | ||||
Journal or Publication Title: | Personalized Medicine | ||||
Publisher: | Future Medicine Ltd. | ||||
ISSN: | 1741-0541 | ||||
Official Date: | July 2008 | ||||
Dates: |
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Volume: | Vol.5 | ||||
Number: | No.4 | ||||
Page Range: | pp. 377-385 | ||||
DOI: | 10.2217/17410541.5.4.377 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Medical College of Wisconsin. Dept. of Ophthalmology, American Health Assistance Foundation |
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