Perkins, Gavin D., Park, Daniel P., Alderson, Derek, Cooke, Matthew (Professor of clinical systems design), Smith, F. Gao (Fang Gao), Gates, Simon, Lamb, S. E. (Sallie E.), Mistry, Dipesh and Thickett, David R. (2011) The Beta Agonist Lung Injury TrIal (BALTI) : prevention trial protocol. Trials, Vol.12 (No.1). p. 79. doi:10.1186/1745-6215-12-79 ISSN 1745-6215.

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Abstract

Background: Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy.
Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell infiltration, activation and inflammatory cytokine release, enhancing basal alveolar fluid clearance and improving alveolar capillary barrier function.
Methods/Design: The Beta Agonist Lung Injury TrIal (prevention) is a multi-centre, randomised, double blind,
placebo-controlled trial. The aim of the trial is to determine in patients undergoing elective transthoracic
oesphagectomy, if treatment with inhaled salmeterol 100 mcg twice daily started at induction of anaesthesia and
continued for 72 hours thereafter compared to placebo affect the incidence of early acute lung injury and other
clinical, resource and patient focused outcomes. The primary outcome will be the development of acute lung
injury within 72 hours of oesophagectomy. The trial secondary outcomes are the development of acute lung injury during the first 28 days post operatively; PaO2: FiO2 ratio; the number of ventilator and organ failure free days, 28 and 90 day survival; health related quality of life and resource utilisation. The study aims to recruit 360 patients from 10 UK centres.

Item Type:	Journal Article
Subjects:	R Medicine > RD Surgery R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Lungs -- Wounds and injuries -- Prevention, Esophagectomy -- Complications, Adrenergic beta agonists
Journal or Publication Title:	Trials
Publisher:	BioMed Central Ltd.
ISSN:	1745-6215
Official Date:	15 March 2011
Dates:	Date Event 15 March 2011 Published
Volume:	Vol.12
Number:	No.1
Page Range:	p. 79
DOI:	10.1186/1745-6215-12-79
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	17 December 2015
Date of first compliant Open Access:	17 December 2015
Funder:	Intensive Care Society (Great Britain) (ICS), National Institute for Health Research (Great Britain) (NIHR)

Data sourced from Thomson Reuters' Web of Knowledge

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