Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent
Smith, Edward M., Wang, X., Littrell, Jack, Eckert, J., Cole, R., Kissebah, Ahmed and Olivier, M. (Michael). (2006) Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent. Genomics, Vol.88 (No.4). pp. 407-414. ISSN 08887543Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ygeno.2006.04.004
The International HapMap Consortium has determined the linkage disequilibrium (LD) patterns of four major human populations. The aim of our investigation was to compare the LD patterns of the HapMap CEPH (Centre d'Etude du Polymorphisme Humain) samples with a family-based cohort of similar ancestry to determine its usefulness as a reference population for disease association studies. We examined four genomic regions on chromosomes 7q, 12p, and 14q totaling 14.3 Mb, initially identified in our linkage study of obesity and the metabolic syndrome. Near identical patterns of LD were detected in both populations. Furthermore, tagSNPs selected based on the HapMap CEPH cohort data capture over 98% of the variants at an r2 > 0.8 in the disease cohort. This confirms the usefulness of the CEPH cohort of the HapMap as a reference sample for further investigations into the genomic variation of populations of Northern European descent.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Faculty of Science > Life Sciences (2010- )
|Library of Congress Subject Headings (LCSH):||Genomics, Human genetics -- Variation -- Europe, Northern, Genotype-environment interaction -- Europe, Northern, Genetics -- Research, Cohort analysis|
|Journal or Publication Title:||Genomics|
|Page Range:||pp. 407-414|
|Funder:||National Institutes of Health (U.S.) (NIH)|
|Grant number:||HL74168 (NIH), DK065598 (NIH)|
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