Torgler, Catherine N., Narasimha, Maithreyi, Knox, Andrea L., Zervas, Christos G., Vernon, Matthew C. and Brown, Nicholas H. (2004) Tensin stabilizes integrin adhesive contacts in drosophila. Developmental Cell, Vol.6 (No.3). pp. 357-369. doi:10.1016/S1534-5807(04)00055-3

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Abstract

We report the functional characterization of the Drosophila ortholog of tensin, a protein implicated in linking integrins to the cytoskeleton and signaling pathways. A tensin null was generated and is viable with wing blisters, a phenotype characteristic of loss of integrin adhesion. In tensin mutants, mechanical abrasion is required during wing expansion to cause wing blisters, suggesting that tensin strengthens integrin adhesion. The localization of tensin requires integrins, talin, and integrin-linked kinase. The N-terminal domain and C-terminal PTB domain of tensin provide essential recruitment signals. The intervening SH2 domain is not localized on its own. We suggest a model where tensin is recruited to sites of integrin adhesion via its PTB and N-terminal domains, localizing the SH2 domain so that it can interact with phosphotyrosine-containing proteins, which stabilize the integrin link to the cytoskeleton.

Item Type:	Journal Article
Subjects:	Q Science > QL Zoology Q Science > QP Physiology
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Drosophila, Integrins, Cell adhesion molecules
Journal or Publication Title:	Developmental Cell
Publisher:	Cell Press
ISSN:	15345807
Official Date:	March 2004
Dates:	Date Event March 2004 Published
Volume:	Vol.6
Number:	No.3
Page Range:	pp. 357-369
DOI:	10.1016/S1534-5807(04)00055-3
Status:	Peer Reviewed
Funder:	Wellcome Trust
Grant number:	64098 (WT)

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