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Tensin stabilizes integrin adhesive contacts in drosophila
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Torgler, Catherine N., Narasimha, Maithreyi, Knox, Andrea L., Zervas, Christos G., Vernon, Matthew C. and Brown, Nicholas H. (2004) Tensin stabilizes integrin adhesive contacts in drosophila. Developmental Cell, Vol.6 (No.3). pp. 357-369. doi:10.1016/S1534-5807(04)00055-3
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Official URL: http://dx.doi.org/10.1016/S1534-5807(04)00055-3
Abstract
We report the functional characterization of the Drosophila ortholog of tensin, a protein implicated in linking integrins to the cytoskeleton and signaling pathways. A tensin null was generated and is viable with wing blisters, a phenotype characteristic of loss of integrin adhesion. In tensin mutants, mechanical abrasion is required during wing expansion to cause wing blisters, suggesting that tensin strengthens integrin adhesion. The localization of tensin requires integrins, talin, and integrin-linked kinase. The N-terminal domain and C-terminal PTB domain of tensin provide essential recruitment signals. The intervening SH2 domain is not localized on its own. We suggest a model where tensin is recruited to sites of integrin adhesion via its PTB and N-terminal domains, localizing the SH2 domain so that it can interact with phosphotyrosine-containing proteins, which stabilize the integrin link to the cytoskeleton.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QL Zoology Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Library of Congress Subject Headings (LCSH): | Drosophila, Integrins, Cell adhesion molecules | ||||
| Journal or Publication Title: | Developmental Cell | ||||
| Publisher: | Cell Press | ||||
| ISSN: | 15345807 | ||||
| Official Date: | March 2004 | ||||
| Dates: |
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| Volume: | Vol.6 | ||||
| Number: | No.3 | ||||
| Page Range: | pp. 357-369 | ||||
| DOI: | 10.1016/S1534-5807(04)00055-3 | ||||
| Status: | Peer Reviewed | ||||
| Funder: | Wellcome Trust | ||||
| Grant number: | 64098 (WT) |
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