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Age-dependent remodelling of ionotropic signalling in cortical astroglia

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Lalo, Ulyana, Palygin, Oleg, North, R. Alan, Verkhratsky, Alexei and Pankratov, Yuriy. (2011) Age-dependent remodelling of ionotropic signalling in cortical astroglia. Aging Cell, Vol.10 (No.3). pp. 392-402. ISSN 1474-9726

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Official URL: http://dx.doi.org/10.1111/j.1474-9726.2011.00682.x

Abstract

Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial. Stimulation of neuronal afferents in mice neocortex triggers complex glial synaptic currents (GSCs) mediated by NMDA, P2X and AMPA receptors and glutamate transporters. In addition, astrocytes demonstrate spontaneous "miniature" GSCs resulting from quantal release of neurotransmitters. Here we demonstrate that maturation and ageing of the brain of mice (from 1 to 21 months) affects the density of ionotropic receptors in astrocytes and their role in GSCs generation. The AMPA receptor-mediated component is the largest in young animals and progressively declines with age. The P2X and NMDA components of GSC are smallest in young, maximal in adult (3 and 6 months old) and once more decrease in old mice, probably reflecting the remodelling of neuronal-glial circuitry. Our results demonstrate that fast synaptic transmission between neurones and astrocytes in neocortex that may be involved in information processing in neuronal-glial networks undergoes remodelling during brain maturation and ageing.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Astrocytes, Cerebral cortex, Brain -- Aging, Neural transmission
Journal or Publication Title:	Aging Cell
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	1474-9726
Date:	June 2011
Volume:	Vol.10
Number:	No.3
Page Range:	pp. 392-402
Identification Number:	10.1111/j.1474-9726.2011.00682.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Grantová agentura České republiky [Grant Agency of the Czech Republic] (GACR)
Grant number:	BB/F021445 (BBSRC), GACR 305/08/1381 (GACR), GACR 305/08/1384 (GACR)
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URI:	http://wrap.warwick.ac.uk/id/eprint/36769