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Regulation of microtubule dynamic instability
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Vaart, Babet van der, Akhmanova, Anna and Straube, Anne. (2009) Regulation of microtubule dynamic instability. Biochemical Society Transactions, Vol.37 (No.5). pp. 1007-1013. ISSN 0300-5127
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Official URL: http://dx.doi.org/10.1042/BST0371007
Abstract
Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differentiation processes. While we only begin to appreciate how the concerted action of MT stabilizers and destabilizers shapes different MT patterns, a clear picture of how individual factors affect the MT structure is emerging. In this paper, we review the current knowledge about proteins that modulate MT dynamic instability.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Kinesin, Microtubules, Cell cycle -- Regulation, Biochemistry |
| Journal or Publication Title: | Biochemical Society Transactions |
| Publisher: | Portland Press Ltd. |
| ISSN: | 0300-5127 |
| Date: | October 2009 |
| Volume: | Vol.37 |
| Number: | No.5 |
| Page Range: | pp. 1007-1013 |
| Identification Number: | 10.1042/BST0371007 |
| Status: | Peer Reviewed |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/36917 |
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