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Tunable thermo-responsive polymer–protein conjugates via a combination of nucleophilic thiol–ene “click” and SET-LRP
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Jones, Mathew W., Gibson, Matthew I., Mantovani, Giuseppe and Haddleton, David M. (2011) Tunable thermo-responsive polymer–protein conjugates via a combination of nucleophilic thiol–ene “click” and SET-LRP. Polymer Chemistry, Vol.2 (No.3). pp. 572-574. doi:10.1039/c0py00329h ISSN 1759-9954.
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Official URL: http://dx.doi.org/10.1039/C0PY00329H
Abstract
Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol–ene “click”, the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer–protein conjugates with tunable thermoresponsive behaviour.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Polymerization, Organic compounds -- Synthesis, Bioconjugates, Nucleophilic reactions, Conjugated polymers | ||||
Journal or Publication Title: | Polymer Chemistry | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1759-9954 | ||||
Official Date: | March 2011 | ||||
Dates: |
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Volume: | Vol.2 | ||||
Number: | No.3 | ||||
Page Range: | pp. 572-574 | ||||
DOI: | 10.1039/c0py00329h | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Warwick Effect Polymers Ltd, European Regional Development Fund (ERDF), HEFCE |
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