Evans, John Spencer, Samudrala, Ram, Walsh, Tiffany R., Oren, Ersin Emre and Tamerler, Candan (2008) Molecular design of inorganic-binding polypeptides. MRS Bulletin, Vol.33 (No.05). pp. 514-518. doi:10.1557/mrs2008.103

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Abstract

Controlled binding and assembly of peptides onto inorganic substrates is at the core of bionanotechnology and biological-materials engineering. Peptides offer several unique advantages for developing future inorganic materials and systems. First, engineered polypeptides can molecularly recognize inorganic surfaces that are distinguishable by shape, crystallography, mineralogy, and chemistry. Second, polypeptides are capable of self-assembly on specific material surfaces leading to addressable molecular architectures. Finally, genetically engineered peptides offer multiple strategies for their functional modification. In this article, we summarize the details and mechanisms involved in combinatorial-polypeptide sequence selection and inorganic-material recognition and affinity, and outline experimental and theoretical approaches and concepts that will help advance this emerging field.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Polypeptides, Polypeptides -- Synthesis, Inorganic compounds -- Synthesis, Peptides, Recombinant molecules
Journal or Publication Title:	MRS Bulletin
Publisher:	Cambridge University Press
ISSN:	0883-7694
Official Date:	2008
Dates:	Date Event 2008 Published
Volume:	Vol.33
Number:	No.05
Page Range:	pp. 514-518
DOI:	10.1557/mrs2008.103
Status:	Peer Reviewed
Access rights to Published version:	Restricted or Subscription Access

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