ARPAC Steering Group (Including: Towner, K. J., Levi, K. and Vlassiadi, M.). (2008) Genetic diversity of carbapenem-resistant isolates of Acinetobacter baumannii in Europe. Clinical Microbiology and Infection, Vol.14 (No.2). pp. 161-167. ISSN 1198743X

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Abstract

In total, 96 carbapenem-resistant isolates of Acinetobacter baumannii were obtained from 25 hospitals in 17 European countries. Imipenem MICs ranged from <4 to 128 mg/L on retesting by Etest, with MICs ≥16 mg/L being associated with the carriage of genes encoding at least one other class D carbapenemase in addition to the intrinsic OXA-51-like enzyme. Molecular typing results obtained by random amplified polymorphic DNA analysis, followed by pulsed-field gel electrophoresis (PFGE) of ApaI-digested chromosomal DNA, were highly congruent, with 17 different PFGE types being delineated at a cut-off similarity level of 85%. With few exceptions, multiple isolates from a single hospital belonged to the same PFGE type. Seven sequence groups were identified among the 96 A. baumannii isolates, with the majority of isolates (n = 81) belonging to the previously defined sequence groups 1 and 2, which each included eight PFGE types. These two multinational lineages included the previously defined European clones II and I, respectively, but the problem of resistant A. baumannii in Europe appeared not to be confined solely to these two European clones. Rather, two broader lineages of carbapenem-resistant A. baumannii now seem to be spreading throughout Europe.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Acinetobacter infections -- Europe, Epidemiology, Drug resistance in microorganisms, Nosocomial infections -- Europe, Microbial genetics
Journal or Publication Title:	Clinical Microbiology and Infection
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	1198743X
Date:	February 2008
Volume:	Vol.14
Number:	No.2
Page Range:	pp. 161-167
Identification Number:	10.1111/j.1469-0691.2007.01911.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Description:	Members of the ARPAC Steering Group were: I. M. Gould (Scientific Co-ordinator), F. M. MacKenzie, M. J. Struelens, H. Goossens, K. J. Towner, J. van der Meer, V. Krcmery, B. Cookson, P. van den Broek, L. Dijkshoorn, J. Vila, G. Cornaglia, F. Baquero, J. Mollison, J. Bruce, D. Wagner and M. Van Looveren.
Funder:	European Commission (EC), Medical Research Council (Great Britain) (MRC)
Grant number:	RA0119 (MRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/36960

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