Aziridine scaffolds for the detection and quantification of hydrogen-bonding interactions through transition-state stabilization
Giordano, Luciana, Hoang, Cam T., Shipman, Michael, Tucker, James H. R. and Walsh, Tiffany R.. (2010) Aziridine scaffolds for the detection and quantification of hydrogen-bonding interactions through transition-state stabilization. Angewandte Chemie International Edition, Vol.50 (No.3). pp. 741-744. ISSN 1433-7851Full text not available from this repository.
Official URL: http://dx.doi.org/10.1002/anie.201005580
Accurately quantifying the strength, distance, and angular dependence of noncovalent interactions is central to understanding numerous aspects of biology and medicine, as well as supramolecular and synthetic chemistry. However, specific weak interactions are often difficult to quantify. Known approaches[1, 2] include computational modeling, informatics, and a variety of experimental techniques. Of the latter, most notable are systems in which internal motions are restricted to two conformations, interchangeable through bond rotation. For example, the “molecular torsion balance”, developed by Wilcox et al., has successfully quantified a range of weak interactions by determining the equilibrium population of these two conformers.[2b–d,g,h] Here, we demonstrate how molecular motion in the form of pyramidal inversion in aziridines may be used for detecting and assessing the strength of an individual H-bond.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QP Physiology
T Technology > TP Chemical technology
|Divisions:||Faculty of Science > Chemistry
Faculty of Science > Centre for Scientific Computing
|Library of Congress Subject Headings (LCSH):||Aziridines, Hydrogen bonding, Supramolecular chemistry|
|Journal or Publication Title:||Angewandte Chemie International Edition|
|Publisher:||Wiley - V C H Verlag GmbH & Co. KGaA|
|Page Range:||pp. 741-744|
|Access rights to Published version:||Restricted or Subscription Access|
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