Gap compensation during accelerated hypofractionated radiotherapy in head and neck cancer
Sanghera, P., Arnfield, John, McConkey, Christopher C. and Hartley, A.. (2008) Gap compensation during accelerated hypofractionated radiotherapy in head and neck cancer. Journal of Radiotherapy in Practice, Vol.7 (No.1). pp. 31-38. ISSN 1460-3969Full text not available from this repository.
Official URL: http://dx.doi.org/10.1017/S1460396907006231
Introduction: In squamous-cell carcinoma (SCC) of the head and neck, unplanned gaps risk prolongation of the overall treatment time (OTT) and reduction in tumour control. This audit determines whether further acceleration can safely be employed to compensate for missed treatments during accelerated hypofractionated radiotherapy.
Methods: Patients receiving accelerated hypofractionated radiotherapy for SCC of the head and neck were prospectively audited. Outcome measures were OTT, degree of compensation and acute toxicity determined by incidence of grade 3 mucositis, prolonged grade 3 mucositis, grade 3 dysphagia and pain.
Results: In the 87 patients identified, the dose administered was 55 Gy in 20 fractions (81 patients), 50 Gy in 20 fractions (1 patient) and 50 Gy in 16 fractions (5 patients). Of those patients receiving 20 fractions, 94% completed within 28 days. Grade 3 mucositis was seen in 56 patients (64%). Compensating for unplanned gaps did not result in any significant increase in toxicity. Administering 6 fractions/week, as compensation, was associated with a lower pain score (p = 0.003) as was receiving 2 fractions on the same day (p = 0.0004).
Conclusions: Accelerated hypofractionation is tolerable with most patients completing treatment within the planned OTT. When unplanned gaps occur, then compensation by further acceleration is possible.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RF Otorhinolaryngology
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Squamous cell carcinoma, Neck -- Cancer -- Treatment, Head -- Cancer -- Treatment, Radiotherapy -- Research|
|Journal or Publication Title:||Journal of Radiotherapy in Practice|
|Publisher:||Cambridge University Press|
|Page Range:||pp. 31-38|
|Access rights to Published version:||Restricted or Subscription Access|
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