Petrou, Stavros and Kupek, Emil. (2009) Estimating preference-based health utilities index mark 3 utility scores for childhood conditions in England and Scotland. Medical Decision Making, Vol.29 (No.3). pp. 291-303. ISSN 0272-989X

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Abstract

Background . A common feature of studies that have compiled lists or catalogues of preference-based health-related quality-of-life weights for inclusion within quality-adjusted life years (QALYs) is their focus upon adult populations. More generally, utility measurement in or on behalf of children has been constrained by a number of methodological concerns. Objective . To augment previous catalogues of preference-based health-related quality-of-life weights by estimating preference-based Health Utilities Index Mark 3 (HUI3) multiattribute utility scores associated with a wide range of childhood conditions. Methods . Data for 2236 children from the ``Disability Survey 2000: Survey of Young People With a Disability and Sport'' formed the basis of this investigation. Ordinary least squares (OLS), Tobit, and censored least absolute deviations (CLAD) regression methods were used to estimate adjusted marginal disutilities for each condition from 2 thresholds: 1) a threshold of 1.0 representing perfect health and 2) a normative childhood utility threshold. Results . Prespecified statistical tests indicated a preference for the OLS regression model over the Tobit and CLAD models. The unadjusted mean, median, 25th percentile and 75th percentile HUI3 multiattribute utility scores and adjusted marginal disutilities are presented for 43 conditions. Notably, based on the OLS estimator, the adjusted marginal disutilities for hydrocephalus; learning and physical disabilities; other syndromes and associations; meningitis, encephalitis, and other infections of the central nervous system; and microcephaly were estimated at —0.889 (95% confidence interval [CI]: —0.727, —1.000), —0.858 (95% CI: —0.727, —0.989), —0.838 (95% CI: —0.668, —1.000), —0.826 (95% CI: —0.677, —0.975), and —0.820 (95% CI: —0.670, —0.970), respectively, when a perfect health threshold was applied, and —0.814 (95% CI: —0.656, —0.979), —0.783 (95% CI: —0.656, —0.918), —0.763 (95% CI: —0.597, —0.937), —0.751 (95% CI: —0.606, —0.904), and —0.745 (95% CI: —0.598, —0.899), respectively, when a normative childhood utility threshold was applied. Conclusion . Our estimates and their associated distributions can be used for the purposes of QALY estimation by analysts conducting economic evaluations within the childhood context.

Item Type:	Journal Article
Subjects:	H Social Sciences > HQ The family. Marriage. Woman R Medicine > RA Public aspects of medicine R Medicine > RJ Pediatrics
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Children -- Health and hygiene -- England -- Statistics, Children -- Health and hygiene -- Scotland -- Statistics, Health status indicators -- England, Health status indicators -- Scotland
Journal or Publication Title:	Medical Decision Making
Publisher:	Sage Publications, Inc.
ISSN:	0272-989X
Date:	2009
Volume:	Vol.29
Number:	No.3
Page Range:	pp. 291-303
Identification Number:	10.1177/0272989X08327398
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Medical Research Council (Great Britain) (MRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/37029

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