Dakin, Helen, Petrou, Stavros, Haggard, Mark, Benge, Sarah and Williamson, I. (Ian), Dr.. (2010) Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire. Quality of Life Research, Vol.19 (No.1). pp. 65-80. ISSN 0962-9343

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Abstract

Purpose To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores. Methods A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores. Results OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions. Conclusion Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RF Otorhinolaryngology
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Otitis media with effusion in children -- Treatment, Quality of life, Health surveys, Health status indicators
Journal or Publication Title:	Quality of Life Research
Publisher:	Springer Netherlands
ISSN:	0962-9343
Date:	February 2010
Volume:	Vol.19
Number:	No.1
Page Range:	pp. 65-80
Identification Number:	10.1007/s11136-009-9558-z
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	NIHR Health Technology Assessment Programme (Great Britain) (NIHR HTA)
URI:	http://wrap.warwick.ac.uk/id/eprint/37039

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