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Differences in outcome between twins and singletons born very preterm : results from a population-based European cohort

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Papiernik, E., Zeitlin, J., Delmas, D., Blondel, Béatrice, Künzel, W., Cuttini, M., Weber, T., Petrou, Stavros, Gortner, L., Kollee, L. and Draper, E. S. (2010) Differences in outcome between twins and singletons born very preterm : results from a population-based European cohort. Human Reproduction, Vol.25 (No.4). pp. 1035-1043. doi:10.1093/humrep/dep430 ISSN 0268-1161.

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Official URL: http://dx.doi.org/10.1093/humrep/dep430

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Abstract

BACKGROUND About 10% of twins are born before 32 weeks of gestation and very preterm birth rates are increasing. Preterm twins tend to have more favourable outcomes than singletons of the same gestational age, but fewer data are available for very preterm infants. This study aims to determine whether outcomes differ between very preterm twins and singletons.

METHOD This study was of a population-based cohort of very preterm babies in 10 European regions in 2003. Mortality and morbidity to discharge from hospital were compared for twins and singletons between 24 and 31 weeks of gestation, who were alive at the onset of labour and without lethal congenital anomalies. Clinical characteristics, pregnancy complications and healthcare factors were taken into consideration.

RESULTS Between 28 and 31 weeks of gestation, mortality and oxygen dependency at 36 corrected weeks of gestation were lower for twins than singletons (3.9 versus 6.5% and 7.1 versus 10.4%, respectively), but this advantage disappeared after controlling for medical and healthcare factors. Hypertension, growth restriction and haemorrhaging were less frequent complications of twin birth and more twins received antenatal corticosteroids and were born in level III units. In contrast, between 24 and 27 weeks of gestation, twins had higher adjusted risks of mortality and Grade III/IV intraventricular haemorrhaging [adjusted ORs 1.5 (95% CI 1.1–2.2) and 1.5 (1.0–2.1)]. These adverse outcomes were concentrated among twins from same sex pairs with discordant birthweights.

CONCLUSIONS Between 24 and 27 weeks of gestation, risks of mortality and severe cranial haemorrhaging were higher for twins than singletons if they were from same sex pairs with discordant birthweights.

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Premature infants -- Europe -- Research, Multiple birth -- Europe -- Research, Twins -- Europe -- Research, Premature infants -- Diseases -- Europe -- Research, Premature infants -- Development -- Europe -- Research, Bronchopulmonary dysplasia -- Europe -- Research
Journal or Publication Title: Human Reproduction
Publisher: Oxford University Press
ISSN: 0268-1161
Official Date: 2010
Dates:
DateEvent
2010Published
Volume: Vol.25
Number: No.4
Page Range: pp. 1035-1043
DOI: 10.1093/humrep/dep430
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: European Commission (EC)
Grant number: QLG4-CT-2001-01907 (EC)

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