Regier, Dean A., Petrou, Stavros, Henderson, Jane, Eddama, O., Patel, Nishma, Strohm, Brenda, Brocklehurst, Peter, Edwards, A. David and Azzopardi, Denis. (2010) Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy. Value in Health, Vol.13 (No.6). pp. 695-702. ISSN 10983015

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Abstract

Objective To estimate the cost-effectiveness (CE) of total body hypothermia plus intensive care versus intensive care alone to treat neonatal encephalopathy. Methods Decision analytic modeling was used to synthesize mortality and morbidity data from three randomized controlled trials, the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY), National Institute of Child Health and Human Development (NICHD), and CoolCap trials. Cost data inputs were informed by TOBY, the sole source of prospectively collected resource utilization data for encephalopathic infants. CE was expressed in terms of incremental cost per disability-free life year (DFLY) gained. Probabilistic sensitivity analysis was performed to generate CE acceptability curves (CEACs). Results Cooling led to a cost increase of £3787 (95% confidence interval [CI]: −2516, 12,360) (€5115; 95% CI: −3398–16,694; US$5344; 95% CI: −3598, 26,356; using 2006 Organisation for Economic Co-operation and Development (OECD) purchasing power parities) and a DFLY gain of 0.19 (95%CI: 0.07–0.31) over the first 18 months after birth. The incremental cost per DFLY gained was £19,931 (€26,920; US$28,124). The baseline CEAC showed that if decision-makers are willing to pay £30,000 for an additional DFLY, there is a 69% probability that cooling is cost-effective. The probability of CE exceeded 99% at this threshold when the throughput of infants was increased to reflect the national incidence of neonatal encephalopathy or when the time horizon of the economic evaluation was extended to 18 years after birth. Conclusions The probability that cooling is a cost-effective treatment for neonatal encephalopathy is finely balanced over the first 18 months after birth but increases substantially when national incidence data or an extended time horizon are considered.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Cold -- Therapeutic use -- Cost effectiveness, Cerebrovascular disease in children -- Treatment, Cerebral anoxia -- Treatment
Journal or Publication Title:	Value in Health
Publisher:	Wiley-Blackwell Publishing, Inc.
ISSN:	10983015
Date:	September 2010
Volume:	Vol.13
Number:	No.6
Page Range:	pp. 695-702
Identification Number:	10.1111/j.1524-4733.2010.00731.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/37047

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