Petrou, Stavros and Gray, Alastair (2011) Economic evaluation using decision analytical modelling : design, conduct, analysis, and reporting. BMJ, Vol.342 . d1766. doi:10.1136/bmj.d1766

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Abstract

Economic evaluations are increasingly conducted alongside randomised controlled trials, providing researchers with individual patient data to estimate cost effectiveness. However, randomised trials do not always provide a sufficient basis for economic evaluations used to inform regulatory and reimbursement decisions. For example, a single trial might not compare all the available options, provide evidence on all relevant inputs, or be conducted over a long enough time to capture differences in economic outcomes (or even measure those outcomes). In addition, reliance on a single trial may mean ignoring evidence from other trials, meta-analyses, and observational studies. Under these circumstances, decision analytical modelling provides an alternative framework for economic evaluation.
Decision analytical modelling compares the expected costs and consequences of decision options by synthesising information from multiple sources and applying mathematical techniques, usually with computer software. The aim is to provide decision makers with the best available evidence to reach a decision—for example, should a new drug be adopted? Following on from our article on trial based economic evaluations, we outline issues relating to the design, conduct, analysis, and reporting
of economic evaluations using decision analytical modelling.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Medical economics, Clinical trials, Medical care, Cost of -- Research, Research -- Methodology, Information modeling, Decision trees
Journal or Publication Title:	BMJ
Publisher:	BMJ Group
ISSN:	0959-8138
Official Date:	11 April 2011
Dates:	Date Event 11 April 2011 Published
Volume:	Vol.342
Page Range:	d1766
DOI:	10.1136/bmj.d1766
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Medical Research Council (Great Britain) (MRC)

Data sourced from Thomson Reuters' Web of Knowledge

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