Petrou, Stavros, Taher, S. E., Abangma, Giselle, Eddama, O. and Bennett, Phillip R.. (2011) Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term. BJOG: An International Journal of Obstetrics & Gynaecology, Vol.118 (No.6). pp. 726-734. ISSN 14700328

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Abstract

Objective  To estimate the cost-effectiveness of prostaglandin E2 (dinoprostone) vaginal gel for the induction of labour at term from the perspective of the UK’s National Health Service. Design  Economic evaluation conducted as part of a randomised controlled trial. Setting  Maternity department at a major teaching hospital in London, UK. Population  A cohort of 165 pregnant women presenting as cephalic between 36+6 and 41+6 weeks of gestation, for whom induction of labour was deemed necessary. Methods  Either 3-mg Prostin E2 vaginal tablets or 1- or 2-mg Prostin E2 vaginal gel were administered at 6-hourly intervals. Main outcome measures  Incremental cost per hour prevented between induction and delivery. The nonparametric bootstrap method was used to construct cost-effectiveness acceptability curves and estimate net benefits at alternative cost-effectiveness thresholds. Results  Women receiving the gel accrued nonsignificantly higher costs (incremental cost £630; bootstrap 95% CI −£353, £2320; P = 0.43), and experienced a significantly reduced interval between induction and delivery (median of 1400 versus 1780 minutes; mean of 1711 versus 2765 minutes; P = 0.03). The incremental cost per hour prevented from induction of labour to delivery was estimated at £36. At a cost-effectiveness threshold of £100 per hour of care prevented, the probability that the gel is cost-effective was estimated at 0.83, and the mean net benefit to the health services was estimated at £1121 (bootstrap 95% CI −£1133, £3379). The results were sensitive to the inclusion of neonatal costs in the analysis and the value of the cost-effectiveness threshold. Notably, excluding neonatal costs increased the probability that the gel is cost-effective at a cost-effectiveness threshold of £100 per hour of care prevented to 0.99. Conclusions  This study suggests that prostaglandin E2 gel is probably more cost-effective than prostaglandin E2 tablets for the induction of labour at term. Given that the results are applicable to the general obstetric population requiring induction of labour at term, decision-makers should consider the likely economic impacts of their implementation.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RG Gynecology and obstetrics
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Medical economics, Medical care, Cost of, Labor, Induced (Obstetrics), Prostaglandins E -- Research, Clinical trials
Journal or Publication Title:	BJOG: An International Journal of Obstetrics & Gynaecology
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	14700328
Date:	May 2011
Volume:	Vol.118
Number:	No.6
Page Range:	pp. 726-734
Identification Number:	10.1111/j.1471-0528.2011.02902.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Medical Research Council (MRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/37062

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