Yuan, Yinyin and Li, Chang-Tsun. (2008) A Bayes random field approach for integrative large-scale regulatory network analysis. Journal of Integrative Bioinformatics, Vol.5 (No.2). ISSN 1613-4516

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Abstract

We present a Bayes-Random Fields framework which is capable of integrating unlimited data sources for discovering relevant network architecture of large-scale networks. The random field potential function is designed to impose a cluster constraint, teamed with a full Bayesian approach for incorporating heterogenous data sets. The probabilistic nature of our framework facilitates robust analysis in order to minimize the influence of noise inherent in the data on the inferred structure in a seamless and coherent manner. This is later proved in its applications to both large-scale synthetic data sets and Saccharomyces Cerevisiae data sets. The analytical and experimental results reveal the varied characteristic of different types of data and refelct their discriminative ability in terms of identifying direct gene interactions.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software Q Science > QC Physics Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH):	Bayesian field theory, Random fields, Computer network architectures, Large scale systems, Data integration (Computer science), Biology -- Data processing, Bioinformatics
Journal or Publication Title:	Journal of Integrative Bioinformatics
ISSN:	1613-4516
Date:	25 August 2008
Volume:	Vol.5
Number:	No.2
Identification Number:	10.2390/biecoll-jib-2008-99
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/37074

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