Stratton, Rebecca C., Squires, Paul E. and Green, Anne K.. (2008) ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIα. Biochemical and Biophysical Research Communications, Vol.368 (No.4). pp. 965-970. ISSN 0006-291X

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Abstract

In rat hepatocytes, atrial natriuretic peptide (ANP) elevates cGMP through activation of particulate guanylyl cyclase and attenuates Ca2+ signals by stimulating net plasma membrane Ca2+ efflux. We show here that ANP-stimulated hepatocyte Ca2+ efflux is mediated by protein kinase G (PKG) isotype I. Furthermore, we show that ANP recruits endogenous PKGIα, but not PKGIβ, to the plasma membrane. These effects are mimicked by 8-bromo-cGMP, but not by the soluble guanylyl cyclase activators, sodium nitroprusside and YC-1. We propose that ANP, through localized cGMP elevation, promotes plasma membrane recruitment of PKGIα, which, in turn, stimulates Ca2+ efflux.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology
Divisions:	Faculty of Medicine > Warwick Medical School > Education Development and Research Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Atrial natriuretic peptides, Liver cells, Cell membranes, Protein kinases
Journal or Publication Title:	Biochemical and Biophysical Research Communications
Publisher:	Academic Press
ISSN:	0006-291X
Date:	2008
Volume:	Vol.368
Number:	No.4
Page Range:	pp. 965-970
Identification Number:	10.1016/j.bbrc.2008.02.030
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	University of Warwick, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/37096

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