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ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIα
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Stratton, Rebecca C., Squires, Paul E. and Green, Anne K. (2008) ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIα. Biochemical and Biophysical Research Communications, Vol.368 (No.4). pp. 965-970. doi:10.1016/j.bbrc.2008.02.030 ISSN 0006-291X.
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Official URL: http://dx.doi.org/10.1016/j.bbrc.2008.02.030
Abstract
In rat hepatocytes, atrial natriuretic peptide (ANP) elevates cGMP through activation of particulate guanylyl cyclase and attenuates Ca2+ signals by stimulating net plasma membrane Ca2+ efflux. We show here that ANP-stimulated hepatocyte Ca2+ efflux is mediated by protein kinase G (PKG) isotype I. Furthermore, we show that ANP recruits endogenous PKGIα, but not PKGIβ, to the plasma membrane. These effects are mimicked by 8-bromo-cGMP, but not by the soluble guanylyl cyclase activators, sodium nitroprusside and YC-1. We propose that ANP, through localized cGMP elevation, promotes plasma membrane recruitment of PKGIα, which, in turn, stimulates Ca2+ efflux.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Atrial natriuretic peptides, Liver cells, Cell membranes, Protein kinases | ||||
Journal or Publication Title: | Biochemical and Biophysical Research Communications | ||||
Publisher: | Academic Press | ||||
ISSN: | 0006-291X | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Vol.368 | ||||
Number: | No.4 | ||||
Page Range: | pp. 965-970 | ||||
DOI: | 10.1016/j.bbrc.2008.02.030 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | University of Warwick, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
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