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Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material
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Collingwood, Joanna F., Chong, R. K. K., Kasama, Takeshi, Cervera-Gontard, Lionel, Dunin-Borkowski, R. E., Perry, George, 1953-, Pósfai, M., Siedlak, Sandra L., Simpson, E. T., Smith, Mark A. and Dobson, Jon. (2008) Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material. Journal of Alzheimer's disease : JAD, Vol.14 (No.2). pp. 235-245. ISSN 1387-2877
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Official URL: http://www.j-alz.com
Abstract
Although it has been known for over 50 years that abnormal concentrations of iron are associated with virtually all neurodegenerative diseases, including Alzheimer's disease, its origin, nature and role have remained a mystery. Here, we use high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray (EDX) spectroscopy and electron energy-loss spectroscopy (EELS), electron tomography, and electron diffraction to image and characterize iron-rich plaque core material - a hallmark of Alzheimer's disease pathology - in three dimensions. In these cores, we unequivocally identify biogenic magnetite and/or maghemite as the dominant iron compound. Our results provide an indication that abnormal iron biomineralization processes are likely occurring within the plaque or the surrounding diseased tissue and may play a role in aberrant peptide aggregation. The size distribution of the magnetite cores implies formation from a ferritin precursor, implicating a malfunction of the primary iron storage protein in the brain.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine T Technology > T Technology (General) |
| Divisions: | Faculty of Science > Engineering |
| Library of Congress Subject Headings (LCSH): | Alzheimer's disease -- Pathogenesis, Three-dimensional imaging, Tomography, Biomedical engineering, Iron compounds |
| Journal or Publication Title: | Journal of Alzheimer's disease : JAD |
| Publisher: | IOS Press |
| ISSN: | 1387-2877 |
| Date: | June 2008 |
| Volume: | Vol.14 |
| Number: | No.2 |
| Page Range: | pp. 235-245 |
| Status: | Peer Reviewed |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37131 |
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