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The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies
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Chapman, James D., Chappell, M. J. (Michael J.) and Evans, Neil D. (2011) The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 37-49. doi:10.1016/j.cmpb.2010.08.019 ISSN 01692607.
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WRAP_Evans_9871863-es-050312-ifacjformalsensitivitychapman2.pdf - Accepted Version Download (612Kb) |
Official URL: http://dx.doi.org/10.1016/j.cmpb.2010.08.019
Abstract
This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies. The analysis is used to compare the potential influence of maternally acquired immunity on various age and time domain observations of infection and serology, with and without seasonality. The results of the analysis indicate that time series observations are largely insensitive to variations in the average duration of this protection, and that age related empirical data are likely to be most appropriate for estimating these characteristics.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology > QR180 Immunology T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Library of Congress Subject Headings (LCSH): | Maternally acquired immunity -- Mathematical models, Immunoglobulins | ||||
Journal or Publication Title: | Computer Methods and Programs in Biomedicine | ||||
Publisher: | Elsevier Ireland Ltd. | ||||
ISSN: | 01692607 | ||||
Official Date: | November 2011 | ||||
Dates: |
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Volume: | Vol.104 | ||||
Number: | No.2 | ||||
Page Range: | pp. 37-49 | ||||
DOI: | 10.1016/j.cmpb.2010.08.019 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 17 December 2015 | ||||
Date of first compliant Open Access: | 17 December 2015 | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
Version or Related Resource: | This item was also submitted for the 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Aalborg, Denmark, Aug 12 - 14, 2009. |
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