Chapman, James D., Chappell, M. J. (Michael J.) and Evans, N. D.. (2011) The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 37-49. ISSN 01692607

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Abstract

This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies. The analysis is used to compare the potential influence of maternally acquired immunity on various age and time domain observations of infection and serology, with and without seasonality. The results of the analysis indicate that time series observations are largely insensitive to variations in the average duration of this protection, and that age related empirical data are likely to be most appropriate for estimating these characteristics.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Maternally acquired immunity -- Mathematical models, Immunoglobulins
Journal or Publication Title:	Computer Methods and Programs in Biomedicine
Publisher:	Elsevier Ireland Ltd.
ISSN:	01692607
Date:	November 2011
Volume:	Vol.104
Number:	No.2
Page Range:	pp. 37-49
Identification Number:	10.1016/j.cmpb.2010.08.019
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
Version or Related Resource:	This item was also submitted for the 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Aalborg, Denmark, Aug 12 - 14, 2009.
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URI:	http://wrap.warwick.ac.uk/id/eprint/37148

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