Godfrey, Keith, Arundel, Philip A., Dong, Zimeng and Bryant, Robert (2010) Modelling the double peak phenomenon in pharmacokinetics. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 62-69. ISSN 0169-2607

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Abstract

Two methods of modelling the Double Peak Phenomenon in pharmacokinetics are described; both are based on compartmental models. The first method assumes that the absorption of the drug from the gut to the systemic plasma varies with the location of the drug in the gut, with negligible absorption through the jejunum. It has the advantage of clear physiological interpretation, but there are a comparatively large number of parameters to be estimated. The second method assumes simultaneous input via two parallel pathways, and has been developed with the aim of reducing the number of parameters in the model. However, this approach lacks the direct relationship to physiology. The two methods are used to model two data sets provided by AstraZeneca and a further data set from the literature, describing the pharmacokinetics of veralipride. For all three data sets, the measurement is of concentration of drug in the systemic plasma following oral administration in solution form.

Item Type:	Submitted Journal Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Pharmacokinetics -- Mathematical models, Parameter estimation
Journal or Publication Title:	Computer Methods and Programs in Biomedicine
Publisher:	Elsevier Ireland Ltd.
ISSN:	0169-2607
Date:	November 2010
Volume:	Vol.104
Number:	No.2
Number of Pages:	8
Page Range:	pp. 62-69
Identification Number:	10.1016/j.cmpb.2010.03.007
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/37152

Data sourced from Thomson Reuters' Web of Knowledge

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