1. Gannon M, Herrera PL, Wright CV (2000) Mosaic Cre-mediated recombination
in pancreas using the pdx-1 enhancer/promoter. Genesis 26: 143–144.
2. Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic
lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.
Development 129: 2447–2457.
3. Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, et al. (2003)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the
mouse. Cancer Cell 4: 437–450.
4. Gannon M, Gamer LW, Wright CV (2001) Regulatory regions driving
developmental and tissue-specific expression of the essential pancreatic gene
pdx1. Dev Biol 238: 185–201.
5. Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, et al. (2002)
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated
insulin secretion. J Biol Chem 277: 11225–11232.
6. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is
required for pancreas development in mice. Nature 371: 606–609.
7. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, et al. (1996) PDX-1 is
required for pancreatic outgrowth and differentiation of the rostral duodenum.
Development 122: 983–995.
8. Larsson LI, Madsen OD, Serup P, Jonsson J, Edlund H (1996) Pancreaticduodenal
homeobox 1 -role in gastric endocrine patterning. Mech Dev 60:
175–184.
9. Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev
Mol Cell Biol 7: 678–689.
10. Lefort K, Dotto GP (2004) Notch signaling in the integrated control of
keratinocyte growth/differentiation and tumor suppression. Semin Cancer Biol
14: 374–386.
11. Dotto GP (2008) Notch tumor suppressor function. Oncogene 27: 5115–5123.
12. Lin MH, Leimeister C, Gessler M, Kopan R (2000) Activation of the Notch
pathway in the hair cortex leads to aberrant differentiation of the adjacent hairshaft
layers. Development 127: 2421–2432.
13. Uyttendaele H, Panteleyev AA, de Berker D, Tobin DT, Christiano AM (2004)
Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk
alopecia. Differentiation 72: 396–409.
14. Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, et al. (2003) Notch1 functions
as a tumor suppressor in mouse skin. Nat Genet 33: 416–421.
15. Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, et al. (2004) gamma-secretase
functions through Notch signaling to maintain skin appendages but is not
required for their patterning or initial morphogenesis. Dev Cell 7: 731–743.
16. Vauclair S, Nicolas M, Barrandon Y, Radtke F (2005) Notch1 is essential for
postnatal hair follicle development and homeostasis. Dev Biol 284: 184–193.
17. Demehri S, Turkoz A, Kopan R (2009) Epidermal Notch1 loss promotes skin
tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16:
55–66.
18. Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, et al. (2001) Loss of presenilin 1
is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc
Natl Acad Sci U S A 98: 10863–10868.
19. Blanpain C, Lowry WE, Pasolli HA, Fuchs E (2006) Canonical notch signaling
functions as a commitment switch in the epidermal lineage. Genes Dev 20:
3022–3035.
20. Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, et al.
(2008) Multiple roles of Notch signaling in the regulation of epidermal
development. Dev Cell 14: 594–604.
21. Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, et al. (1999) Deficient T
cell fate specification in mice with an induced inactivation of Notch1. Immunity
10: 547–558.
22. Besseyrias V, Fiorini E, Strobl LJ, Zimber-Strobl U, Dumortier A, et al. (2007)
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment
and maturation. J Exp Med 204: 331–343.
23. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter
strain. Nat Genet 21: 70–71.
24. Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, et al. (2005)
Trp53R172H and KrasG12D cooperate to promote chromosomal instability
and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7:
469–483.
25. Greenhalgh DA, Rothnagel JA, Quintanilla MI, Orengo CC, Gagne TA, et al.
(1993) Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in
transgenic mice by a targeted v-Ha-ras oncogene. Mol Carcinog 7: 99–110.
26. Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo AA, Gutkind JS
(2004) Conditional expression of K-ras in an epithelial compartment that
includes the stem cells is sufficient to promote squamous cell carcinogenesis.
Cancer Res 64: 8804–8807.
27. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, et al. (2004)
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread
neoplastic and developmental defects. Cancer Cell 5: 375–387.
28. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, et al. (1980)
Calcium regulation of growth and differentiation of mouse epidermal cells in
culture. Cell 19: 245–254.
29. Wescott MP, Rovira M, Reichert M, von Burstin J, Means A, et al. (2009)
Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription
factor. Mol Biol Cell 20: 4838–4844.
30. Buettner M, Dimmler A, Magener A, Brabletz T, Stolte M, et al. (2004) Gastric
PDX-1 expression in pancreatic metaplasia and endocrine cell hyperplasia in
atrophic corpus gastritis. Mod Pathol 17: 56–61.
31. Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, et al. (2003)
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription
factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.
Diabetes 52: 2896–2904.
32. Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, et al.
(1999) Glucose stimulates translocation of the homeodomain transcription factor
PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. J Biol Chem
274: 1011–1016.
33. Tarutani M, Cai T, Dajee M, Khavari PA (2003) Inducible activation of Ras
and Raf in adult epidermis. Cancer Res 63: 319–323.
34. Oskarsson T, Essers MA, Dubois N, Offner S, Dubey C, et al. (2006) Skin
epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but
can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev
20: 2024–2029.
35. Tarutani M, Itami S, Okabe M, Ikawa M, Tezuka T, et al. (1997) Tissue-specific
knockout of the mouse Pig-a gene reveals important roles for GPI-anchored
proteins in skin development. Proc Natl Acad Sci U S A 94: 7400–7405.
36. Lowell S, Jones P, Le Roux I, Dunne J, Watt FM (2000) Stimulation of human
epidermal differentiation by delta-notch signalling at the boundaries of stem-cell
clusters. Curr Biol 10: 491–500.
37. Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, et al. (2001)
Notch signaling is a direct determinant of keratinocyte growth arrest and entry
into differentiation. EMBO J 20: 3427–3436.
38. Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ (1998) Distinct
expression patterns of notch family receptors and ligands during development of
the mammalian inner ear. Mech Dev 78: 159–163.
39. Hamada Y, Kadokawa Y, Okabe M, Ikawa M, Coleman JR, et al. (1999)
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic
lethality. Development 126: 3415–3424.
40. Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC,
et al. (2005) Integration of Notch 1 and calcineurin/NFAT signaling pathways in
keratinocyte growth and differentiation control. Dev Cell 8: 665–676.
41. Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, et al. (1998) Inhibitory
function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes
independent of cell cycle control. Science 280: 1069–1072.
42. Chan EF, Gat U, McNiff JM, Fuchs E (1999) A common human skin tumour is
caused by activating mutations in beta-catenin. Nat Genet 21: 410–413.
43. Reya T, Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434:
843–850.
44. Bagheri MM, Safai B (2001) Cutaneous malignancies of keratinocytic origin.
Clin Dermatol 19: 244–252.
45. Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, et al. (2009)
Direct inhibition of the NOTCH transcription factor complex. Nature 462:
182–188.
46. Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, et al. (2010)
Therapeutic antibody targeting of individual Notch receptors. Nature 464:
1052–1057.
47. Chigurupati S, Arumugam TV, Son TG, Lathia JD, Jameel S, et al. (2007)
Involvement of notch signaling in wound healing. PLoS One 2: e1167.
48. Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, et al. (2008)
Conditional ablation of Notch signaling in pancreatic development. Development
135: 2757–2765.
49. Geisler F, Nagl F, Mazur PK, Lee M, Zimber-Strobl U, et al. (2008) Liverspecific
inactivation of Notch2, but not Notch1, compromises intrahepatic bile
duct development in mice. Hepatology 48: 607–616.
50. Kopan R, Ilagan MX (2009) The canonical Notch signaling pathway: unfolding
the activation mechanism. Cell 137: 216–233.
51. Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, et al. (2004) Notch1 and
notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 64:
7787–7793.
52. Mazur PK, Einwa¨chter H, Lee M, Sipos B, Nakhai H, et al. (2010) Notch2 is
required for PanIN progression and development of pancreatic ductal
adenocarcinoma. Proc Natl Acad Sci U S A in press.
53. Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, et al. (2008)
Notch signaling is required for exocrine regeneration after acute pancreatitis.
Gastroenterology 134: 544–555.
54. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (2001) beta-
Catenin controls hair follicle morphogenesis and stem cell differentiation in the
skin. Cell 105: 533–545.
55. Novak A, Guo C, Yang W, Nagy A, Lobe CG (2000) Z/EG, a double reporter
mouse line that expresses enhanced green fluorescent protein upon Cremediated
excision. Genesis 28: 147–155.
56. Siveke JT, Einwachter H, Sipos B, Lubeseder-Martellato C, Kloppel G, et al.
(2007) Concomitant pancreatic activation of Kras(G12D) and Tgfa results in
cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 12:
266–279.
57. Hakkinen L, Koivisto L, Larjava H (2001) An improved method for culture of
epidermal keratinocytes from newborn mouse skin. Methods Cell Sci 23:
189–196.
58. Sakai T, Johnson KJ, Murozono M, Sakai K, Magnuson MA, et al. (2001)
Plasma fibronectin supports neuronal survival and reduces brain injury following
transient focal cerebral ischemia but is not essential for skin-wound healing and
hemostasis. Nat Med 7: 324–330.