Khovanov, I. A., Khovanova, N. A., McClintock, P. V. E. and Stefanovska, A.. (2009) Intrinsic dynamics of heart regulatory systems on short timescales : from experiment to modelling. Journal of Statistical Mechanics: Theory and Experiment, Vol.2009 (No.1). Article: P01016. ISSN 1742-5468

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Abstract

We discuss open problems related to the stochastic modelling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider first the cardiac control system on short timescales via an analysis of HRV within the framework of a random walk approach. Our experiments show that HRV on timescales of less than a minute takes the form of free diffusion, close to Brownian motion, which can be described as a non-stationary process with stationary increments. Secondly, we consider the inverse problem of modelling the state of the control system so as to reproduce the experimentally observed HRV statistics of. We discuss some simple toy models and identify open problems for the modelling of heart dynamics.

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Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics Q Science > QP Physiology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Heart -- Mathematical models, Heart beat -- Mathematical models
Journal or Publication Title:	Journal of Statistical Mechanics: Theory and Experiment
Publisher:	Institute of Physics Publishing Ltd.
ISSN:	1742-5468
Date:	January 2009
Volume:	Vol.2009
Number:	No.1
Number of Pages:	15
Page Range:	Article: P01016
Identification Number:	10.1088/1742-5468/2009/01/P01016
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Wellcome Trust (London, England)
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URI:	http://wrap.warwick.ac.uk/id/eprint/37161

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