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Intrinsic dynamics of heart regulatory systems on short timescales : from experiment to modelling
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Khovanov, I. A., Khovanova, N. A., McClintock, P. V. E. and Stefanovska, A. (2009) Intrinsic dynamics of heart regulatory systems on short timescales : from experiment to modelling. Journal of Statistical Mechanics: Theory and Experiment, Vol.2009 (No.1). Article: P01016. doi:10.1088/1742-5468/2009/01/P01016
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WRAP_Khovanova_0973918-es-121211-n.khovanova0901.pdf - Accepted Version - Requires a PDF viewer. Download (383Kb) |
Official URL: http://dx.doi.org/10.1088/1742-5468/2009/01/P01016
Abstract
We discuss open problems related to the stochastic modelling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider first the cardiac control system on short timescales via an analysis of HRV within the framework of a random walk approach. Our experiments show that HRV on timescales of less than a minute takes the form of free diffusion, close to Brownian motion, which can be described as a non-stationary process with stationary increments. Secondly, we consider the inverse problem of modelling the state of the control system so as to reproduce the experimentally observed HRV statistics of. We discuss some simple toy models and identify open problems for the modelling of heart dynamics.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Heart -- Mathematical models, Heart beat -- Mathematical models | ||||
| Journal or Publication Title: | Journal of Statistical Mechanics: Theory and Experiment | ||||
| Publisher: | Institute of Physics Publishing Ltd. | ||||
| ISSN: | 1742-5468 | ||||
| Official Date: | January 2009 | ||||
| Dates: |
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| Volume: | Vol.2009 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 15 | ||||
| Page Range: | Article: P01016 | ||||
| DOI: | 10.1088/1742-5468/2009/01/P01016 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Wellcome Trust (London, England) |
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