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A novel broad-spectrum treatment for respiratory virus infections : influenza-based defective interfering virus provides protection against pneumovirus infection in vivo
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Easton, A. J. (Andrew J.), Scott, P. D. (Paul D.), Edworthy, Nicole Lynn, Meng, Bo, Marriott, Anthony C. and Dimmock, N. J. (2011) A novel broad-spectrum treatment for respiratory virus infections : influenza-based defective interfering virus provides protection against pneumovirus infection in vivo. Vaccine, Vol.29 (No.15). pp. 2777-2784. doi:10.1016/j.vaccine.2011.01.102 ISSN 0264410X.
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Official URL: http://dx.doi.org/10.1016/j.vaccine.2011.01.102
Abstract
Respiratory viruses represent a major clinical burden. Few vaccines and antivirals are available, and the rapid appearance of resistant viruses is a cause for concern. We have developed a novel approach which exploits defective viruses (defective interfering (DI) or protecting viruses). These are naturally occurring deletion mutants which are replication-deficient and multiply only when coinfection with a genetically compatible infectious virus provides missing function(s) in trans. Interference/protection is believed to result primarily from genome competition and is therefore usually confined to the virus from which the DI genome originated. Using intranasally administered protecting influenza A virus we have successfully protected mice from lethal in vivo infection with influenza A viruses from several different subtypes [1]. Here we report, contrary to expectation, that protecting influenza A virus also protects in vivo against a genetically unrelated respiratory virus, pneumonia virus of mice, a pneumovirus from the family Paramyxoviridae. A single dose that contains 1 μg of protecting virus protected against lethal infection. This protection is achieved by stimulating type I interferon and possibly other elements of innate immunity. Protecting virus thus has the potential to protect against all interferon-sensitive respiratory viruses and all influenza A viruses.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Respiratory infections -- Treatment, Antiviral agents, Paramyxoviruses, Influenza A virus | ||||
Journal or Publication Title: | Vaccine | ||||
Publisher: | Elsevier BV | ||||
ISSN: | 0264410X | ||||
Official Date: | 24 March 2011 | ||||
Dates: |
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Volume: | Vol.29 | ||||
Number: | No.15 | ||||
Page Range: | pp. 2777-2784 | ||||
DOI: | 10.1016/j.vaccine.2011.01.102 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 17 December 2015 | ||||
Date of first compliant Open Access: | 17 December 2015 | ||||
Funder: | Medical Research Council (Great Britain) (MRC), Mercia Spinner |
Data sourced from Thomson Reuters' Web of Knowledge
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