Fan, Xiaolei, Lapkin, Alexei and Plucinski, Pawel K.. (2009) Liquid phase hydrogenation in a structured multichannel reactor. Catalysis Today, Vol.147 (No.S1). S313-S318. ISSN 0920-5861

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Abstract

A compact, structured, multichannel reactor was tested for two exemplary reactions: the selective hydrogenation of aromatic aldehyde and the tandem C–C coupling–hydrogenation. In the case of hydrogenation reaction up to 50% yield with ca. 96% selectivity was attained in a single pass (single channel of 10 cm length of catalytic bed) at a liquid phase residence time of ca. 10 s, proving the effectiveness of the designed reactor. By controlling the point of injection of hydrogen into the reactor an increase in the yield of hydrogenation up to 73% was achieved using two channels in a consecutive mode. The designed compact reactor was also proven to be an excellent tool for kinetic studies: the kinetics of the three-phase hydrogenation was evaluated showing: (i) reaction limitation for applied reaction conditions, (ii) Langmuir–Hinshelwood mechanism of hydrogenation, and finally (iii) the dominating role of adsorption of reactant and absorption of hydrogen in the mechanism of hydrogenation at higher temperatures. Furthermore, the compact reactor was also successfully used for conducting sequential coupling Heck reaction with consecutive hydrogenation of double C–C bond. A stepwise conversion of the substrates to the final product was achieved with ca. 6 min residence time at relatively low temperature and pressure. In conclusion, the developed structured compact reactor was demonstrated as a promising alternative to replace conventional batch reactors and establish continuous synthesis of pharmaceutical intermediates and specialty chemicals.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Hydrogenation, Microreactors, Heat -- Transmission, Multiphase flow, Catalysts
Journal or Publication Title:	Catalysis Today
Publisher:	Elsevier BV
ISSN:	0920-5861
Date:	September 2009
Volume:	Vol.147
Number:	No.S1
Number of Pages:	6
Page Range:	S313-S318
Identification Number:	10.1016/j.cattod.2009.07.048
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
Grant number:	EP/DO64937/1 (EPSRC)
Version or Related Resource:	This paper was also given at the 3rd International Conference on Structured Catalysts and Reactors, ICOSCAR-3, Ischia, Italy, 27-30 September 2009.
Conference Paper Type:	Paper
Title of Event:	3rd International Conference on Structured Catalysts and Reactors, ICOSCAR-3
Type of Event:	Conference
Location of Event:	Ischia, Italy
Date(s) of Event:	27-30 Sept 2009
URI:	http://wrap.warwick.ac.uk/id/eprint/37176

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