Coupling of Heck and hydrogenation reactions in a continuous compact reactor
Fan, Xiaolei, Manchon, Maria Gonzalez, Wilson, Karen, Tennison, Steve, Kozynchenko, Alexander, Lapkin, Alexei and Plucinski, Pawel K.. (2009) Coupling of Heck and hydrogenation reactions in a continuous compact reactor. Journal of Catalysis, Vol.267 (No.2). pp. 114-120. ISSN 0021-9517Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.jcat.2009.07.019
A continuous multi-step synthesis of 1,2-diphenylethane was performed sequentially in a structured compact reactor. This process involved a Heck C–C coupling reaction followed by the addition of hydrogen to perform reduction of the intermediate obtained in the first step. Both of the reactions were catalysed by microspherical carbon-supported Pd catalysts. Due to the integration of the micro-heat exchanger, the static mixer and the mesoscale packed-bed reaction channel, the compact reactor was proven to be an intensified tool for promoting the reactions. In comparison with the batch reactor, this flow process in the compact reactor was more efficient as: (i) the reaction time was significantly reduced (ca. 7 min versus several hours), (ii) no additional ligands were used and (iii) the reaction was run at lower operational pressure and temperature. Pd leached in the Heck reaction step was shown to be effectively recovered in the following hydrogenation reaction section and the catalytic activity of the system can be mostly retained by reverse flow operation.
|Item Type:||Journal Article|
|Subjects:||T Technology > TP Chemical technology|
|Divisions:||Faculty of Science > Engineering|
|Library of Congress Subject Headings (LCSH):||Hydrogenation, Heck reaction, Microreactors|
|Journal or Publication Title:||Journal of Catalysis|
|Official Date:||October 2009|
|Number of Pages:||7|
|Page Range:||pp. 114-120|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC)|
|Grant number:||EP/C519736/1 (EPSRC)|
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