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Optical tweezers for single cells
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Zhang, Hu and Liu, Kuo-Kang. (2008) Optical tweezers for single cells. Journal of The Royal Society Interface, Vol.5 (No.24). pp. 671-690. ISSN 1742-5689
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Official URL: http://dx.doi.org/10.1098/rsif.2008.0052
Abstract
Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include non-contact force for cell manipulation, force resolution as accurate as 100 aN and amiability to liquid medium environments. Their wide range of applications, such as transporting foreign materials into single cells, delivering cells to specific locations and sorting cells in microfluidic systems, are reviewed in this article. Recent developments of OT for nanomechanical characterization of various biological cells are discussed in terms of both their theoretical and experimental advancements. The future trends of employing OT in single cells, especially in stem cell delivery, tissue engineering and regenerative medicine, are prospected. More importantly, current limitations and future challenges of OT for these new paradigms are also highlighted in this review.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology T Technology > TJ Mechanical engineering and machinery T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Faculty of Science > Engineering |
| Library of Congress Subject Headings (LCSH): | Optical tweezers, Micrurgy, Microfluidic devices, Cytology -- Technique, Biomechanics, Tissue engineering |
| Journal or Publication Title: | Journal of The Royal Society Interface |
| Publisher: | The Royal Society Publishing |
| ISSN: | 1742-5689 |
| Date: | 6 July 2008 |
| Volume: | Vol.5 |
| Number: | No.24 |
| Number of Pages: | 20 |
| Page Range: | pp. 671-690 |
| Identification Number: | 10.1098/rsif.2008.0052 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) |
| Grant number: | BB/D014786/1 (BBSRC, EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37213 |
Data sourced from Thomson Reuters' Web of Knowledge
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