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Correlations between the experimental and numerical investigations on the mechanical properties of erythrocyte by laser stretching
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Li, C. (Chuan), Liu, Yong-Ping, Liu, Kuo-Kang and Lai, A. C. K.. (2008) Correlations between the experimental and numerical investigations on the mechanical properties of erythrocyte by laser stretching. IEEE Transactions on NanoBioscience, Vol.7 (No.1). pp. 80-90. ISSN 1536-1241
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Official URL: http://dx.doi.org/10.1109/TNB.2008.2000152
Abstract
The deformation and mechanical properties of the erythrocytes are studied experimentally and numerically. For the experimental part, an osmotic swollen spherical erythrocyte was attached with a pair of silica beads, and then stretched at two opposite ends by a laser trap. The purpose of this experiment is to find the empirical correlation between the stretching force and the cell deformation in terms of the transverse strain, which is a measure of the change of radius in a spherical cell along its equator. Experimental results show the cell shape become more oblate, elliptic as the stretching force increases. On the numerical front, a physical model from the original work by Pamplona and Calladine for the lipsomes was extended to simulate the deformation of the cell membrane. Numerical analyses were performed to solve the nondimensionalized governing equations with proper boundary conditions imposed to simulate the experimental conditions. The simulated results indicate that at high tensile stiffness, the cell can deform into a spindle shape with negative curvature close to the ends of stretch. Finally, the experimental data and the simulated results were correlated through optimization by minimizing their discrepancy at various values of the shear stiffness. The optimal value of shear stiffness was found in the range of 2.35 ~ 4.29 X 10-6 N-m-1, which is comparable with those values reported in the literature.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology T Technology > TK Electrical engineering. Electronics Nuclear engineering T Technology > TP Chemical technology |
| Divisions: | Faculty of Science > Engineering |
| Library of Congress Subject Headings (LCSH): | Cell membranes, Erythrocytes, Erythrocytes -- Biotechnology, Erythrocytes -- Deformability, Numerical analysis, Optical tweezers |
| Journal or Publication Title: | IEEE Transactions on NanoBioscience |
| Publisher: | IEEE |
| ISSN: | 1536-1241 |
| Date: | March 2008 |
| Volume: | Vol.7 |
| Number: | No.1 |
| Number of Pages: | 11 |
| Page Range: | pp. 80-90 |
| Identification Number: | 10.1109/TNB.2008.2000152 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) |
| Grant number: | BB/D014786/1 (BBSRC, EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37220 |
Data sourced from Thomson Reuters' Web of Knowledge
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