Li, C. (Chuan) and Liu, Kuo-Kang. (2008) Nanomechanical characterization of red blood cells using optical tweezers. Journal of Materials Science: Materials in Medicine, Vol.19 (No.4). pp. 1529-1535. ISSN 0957-4530

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Abstract

Deformation behaviours of red blood cells (RBCs) have been studied by applying stretching forces via optical tweezers. Combined with finite-element analyses (FEA), the RBCs’ mechanical properties are determined quantitatively based on a best fitting between the experimental deformed geometries and the simulated counterparts. Experimentally, a silica beads attached erythrocyte is optical-mechanically stretched to different lengths. On the theoretical front, a large deformation model with Mooney-Rivlin constitutive equations has been simulated by using FEA to predict the cell deformation geometries. The numerically simulated transverse and longitudinal strains which are in a good agreement with the experimental measurements facilitate the determination of elastic constants of the cells.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Optical tweezers, Erythrocytes -- Mechanical properties, Erythrocytes -- Biotechnology, Erythrocytes -- Deformability
Journal or Publication Title:	Journal of Materials Science: Materials in Medicine
Publisher:	Springer New York LLC
ISSN:	0957-4530
Official Date:	April 2008
Volume:	Vol.19
Number:	No.4
Number of Pages:	7
Page Range:	pp. 1529-1535
Identification Number:	10.1007/s10856-008-3382-9
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC)
Grant number:	BB/D014786/1 (BBSRC, EPSRC)
Version or Related Resource:	Paper also presented at the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007.
Conference Paper Type:	Paper
Title of Event:	21st European Conference on Biomaterials
Type of Event:	Conference
Location of Event:	Brighton, UK
Date(s) of Event:	9-13 Sept 2007
URI:	http://wrap.warwick.ac.uk/id/eprint/37229

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