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Nanomechanical characterization of red blood cells using optical tweezers

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Li, C. (Chuan) and Liu, Kuo-Kang (2008) Nanomechanical characterization of red blood cells using optical tweezers. Journal of Materials Science: Materials in Medicine, Vol.19 (No.4). pp. 1529-1535. doi:10.1007/s10856-008-3382-9

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Official URL: http://dx.doi.org/10.1007/s10856-008-3382-9

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Abstract

Deformation behaviours of red blood cells (RBCs) have been studied by applying stretching forces via optical tweezers. Combined with finite-element analyses (FEA), the RBCs’ mechanical properties are determined quantitatively based on a best fitting between the experimental deformed geometries and the simulated counterparts. Experimentally, a silica beads attached erythrocyte is optical-mechanically stretched to different lengths. On the theoretical front, a large deformation model with Mooney-Rivlin constitutive equations has been simulated by using FEA to predict the cell deformation geometries. The numerically simulated transverse and longitudinal strains which are in a good agreement with the experimental measurements facilitate the determination of elastic constants of the cells.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Optical tweezers, Erythrocytes -- Mechanical properties, Erythrocytes -- Biotechnology, Erythrocytes -- Deformability
Journal or Publication Title: Journal of Materials Science: Materials in Medicine
Publisher: Springer New York LLC
ISSN: 0957-4530
Official Date: April 2008
Dates:
DateEvent
April 2008Published
Volume: Vol.19
Number: No.4
Number of Pages: 7
Page Range: pp. 1529-1535
DOI: 10.1007/s10856-008-3382-9
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC)
Grant number: BB/D014786/1 (BBSRC, EPSRC)
Version or Related Resource: Paper also presented at the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007.
Conference Paper Type: Paper
Title of Event: 21st European Conference on Biomaterials
Type of Event: Conference
Location of Event: Brighton, UK
Date(s) of Event: 9-13 Sept 2007

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