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Nanomechanical characterization of red blood cells using optical tweezers
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Li, C. (Chuan) and Liu, Kuo-Kang (2008) Nanomechanical characterization of red blood cells using optical tweezers. Journal of Materials Science: Materials in Medicine, Vol.19 (No.4). pp. 1529-1535. doi:10.1007/s10856-008-3382-9
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Official URL: http://dx.doi.org/10.1007/s10856-008-3382-9
Abstract
Deformation behaviours of red blood cells (RBCs) have been studied by applying stretching forces via optical tweezers. Combined with finite-element analyses (FEA), the RBCs’ mechanical properties are determined quantitatively based on a best fitting between the experimental deformed geometries and the simulated counterparts. Experimentally, a silica beads attached erythrocyte is optical-mechanically stretched to different lengths. On the theoretical front, a large deformation model with Mooney-Rivlin constitutive equations has been simulated by using FEA to predict the cell deformation geometries. The numerically simulated transverse and longitudinal strains which are in a good agreement with the experimental measurements facilitate the determination of elastic constants of the cells.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Optical tweezers, Erythrocytes -- Mechanical properties, Erythrocytes -- Biotechnology, Erythrocytes -- Deformability | ||||
| Journal or Publication Title: | Journal of Materials Science: Materials in Medicine | ||||
| Publisher: | Springer New York LLC | ||||
| ISSN: | 0957-4530 | ||||
| Official Date: | April 2008 | ||||
| Dates: |
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| Volume: | Vol.19 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 1529-1535 | ||||
| DOI: | 10.1007/s10856-008-3382-9 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) | ||||
| Grant number: | BB/D014786/1 (BBSRC, EPSRC) | ||||
| Version or Related Resource: | Paper also presented at the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007. | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 21st European Conference on Biomaterials | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Brighton, UK | ||||
| Date(s) of Event: | 9-13 Sept 2007 |
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