Mechanical characterization of biomimetic membranes by micro-shaft poking
Liu, Kuo-Kang, Yang, Y. (Ying), Siamantouras, Eleftherios and Ahearne, Mark. (2009) Mechanical characterization of biomimetic membranes by micro-shaft poking. Journal of The Royal Society Interface, Vol.6 (No.34). pp. 471-478. ISSN 1742-5689Full text not available from this repository.
Official URL: http://dx.doi.org/10.1098/rsif.2008.0317
The popularity of biomimetic membranes has recently increased due to their biomedical applications such as tissue engineering/regenerative medicine and biosensors. Characterization of the viscoelastic properties of these membranes is important in developing functional membranes. A new micro-shaft poking technique has been developed, which is free from the complication of substrate backing, and which is normally an intractable problem in conventional indentation testing of membrane materials. A tailored indentation apparatus with a spherical indenter and a force resolution and displacement of 1 μN and 1 μm was constructed. Alginate and agarose were used to fabricate biomimetic membranes. Chicken epidermis was examined to represent a real biological tissue. The results show that the elastic modulus increased with concentration in hydrogels. Epidermis moduli appeared to increase with increased strain. Stress relaxation tests have also been conducted to examine the time-dependent behaviours of various hydrogels and a viscoelastic model has been correspondingly developed and applied to describe the experimental results. Potential applications of this new instrument to other membranes, both artificial and biological, have also been addressed.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
T Technology > TP Chemical technology
|Divisions:||Faculty of Science > Engineering|
|Library of Congress Subject Headings (LCSH):||Colloids, Biomimetic materials -- Mechanical properties, Tissues -- Mechanical properties, Membranes (Technology)|
|Journal or Publication Title:||Journal of The Royal Society Interface|
|Publisher:||The Royal Society Publishing|
|Number of Pages:||8|
|Page Range:||pp. 471-478|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||North Staffordshire Research and Development Consortium (NSRDC)|
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