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A lumped-parameter model of the cerebrospinal system for investigating arterial-driven flow in posttraumatic syringomyelia
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Elliott, N. S. J., Lockerby, Duncan A. and Brodbelt, A. R. (2011) A lumped-parameter model of the cerebrospinal system for investigating arterial-driven flow in posttraumatic syringomyelia. Medical Engineering & Physics, Vol.33 (No.7). pp. 874-882. doi:10.1016/j.medengphy.2010.07.009
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Official URL: http://dx.doi.org/10.1016/j.medengphy.2010.07.009
Abstract
Fluid transport in syringomyelia has remained enigmatic ever since the disease was first identified some three centuries ago. However, accumulating evidence in the last decade from animal studies implicates arterial pulsations in syrinx formation. In particular, it has been suggested that a phase difference between the pressure pulse in the spinal subarachnoid space and the perivascular spaces, due to a pathologically disturbed cerebrospinal fluid (CSF) or blood supply, could result in a net influx of CSF into the spinal cord (SC). A lumped-parameter model is developed of the cerebrospinal system to investigate this conjecture. It is found that although this phase-lag mechanism may operate, it requires the SC to have an intrinsic storage capacity due to the collapsibility of the contained venous reservoir. This net flux is associated with a higher mean pressure in the SC than the SSS which is maintained in the periodic steady state. According to our simulations the mechanical perturbations of arachnoiditis exacerbate the phase-lag effect, which may be partially alleviated by the presence of a posttraumatic syrinx and more completely by a syringo-subarachnoid shunt.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Cerebrospinal fluid pressure -- Mathematical models, Syringomyelia -- Mathematical models, Fluid dynamics | ||||
| Journal or Publication Title: | Medical Engineering & Physics | ||||
| Publisher: | Elsevier Ltd. | ||||
| ISSN: | 13504533 | ||||
| Official Date: | September 2011 | ||||
| Dates: |
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| Volume: | Vol.33 | ||||
| Number: | No.7 | ||||
| Page Range: | pp. 874-882 | ||||
| DOI: | 10.1016/j.medengphy.2010.07.009 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Version or Related Resource: | Presented in part as: Elliott, N.S.J., Lockerby, D.A. and Brodbelt, A.R. (2009). A lumped-parameter model of the cerebrospinal system for simulating syringomyelia. MNF2009: 2nd Micro and Nano Flows Conference. ; And: Elliott, N.S.J., Lockery, D.A. and Brodbelt, A.R. (2009). Arterial-pulsation driven flow in syringomyelia—a lumped-parameter model. In: Dössel, O., Schlegel, W.C., eds. World Congress on Medical Physics and Biomedical Engineeering, IFMBE Proceedings, vol. 25., pp. 1699–1702. |
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