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A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
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Chataway, J., Nicholas, R., Todd, S., Miller, D. H., Parsons, Nicholas R., Valdes-Marquez, E., Stallard, Nigel and Friede, Tim. (2011) A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Multiple Sclerosis Journal, Vol.17 (No.1). pp. 81-88. ISSN 1352-4585
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Official URL: http://dx.doi.org/10.1177/1352458510382129
Abstract
Background:Adaptive seamless designs (ASDs) have been proposed to test multiple candidate compounds using an interim decision point which allows potentially effective therapies to be taken into the next design stage and to be assessed using a phase III outcome.
Objective:To determine whether ASDs are feasible in secondary progressive multiple sclerosis (SPMS) and to compare them with conventional trial designs.
Methods:We develop an innovative adaptive trial design for SPMS, which builds on recent developments in statistical methodology. A literature search and individual clinical datasets were used to inform a framework to run simulations to evaluate the proposed design.
Results:ASDs are feasible in SPMS with MRI informing an interim decision point and Expanded Disability Status Scale (EDSS) as the final disability endpoint. Furthermore ASDs are more efficient than conventional designs with sample size savings of up to 40%. Sample sizes of 1000–1250 patients are sufficient to test up to four experimental treatments. Controlled recruitment is important to realize the full benefits of ASDs.
Conclusions:Although more complex in design, ASDs have the potential to be more efficient and more powerful than conventional designs.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Multiple Sclerosis Journal |
| Publisher: | Sage Publications Ltd. |
| ISSN: | 1352-4585 |
| Official Date: | January 2011 |
| Volume: | Vol.17 |
| Number: | No.1 |
| Page Range: | pp. 81-88 |
| Identification Number: | 10.1177/1352458510382129 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | NIHR Biomedical Research Centre , MS Society of Great Britain , Northern Ireland , Department of Health's NIHR Biomedical Research Centers |
| Grant number: | 878/08 913/09 (Northern Ireland) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37296 |
Data sourced from Thomson Reuters' Web of Knowledge
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