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Anti-hypertensive drugs as disease-modifying agents for Parkinson's disease : evidence from observational studies and clinical trials
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Rees, Karen, Stowe, Rebecca, Patel, Smitaa, Ives, Natalie, Breen, Kieran, Ben-Shlomo, Yoav and Clarke, Carl E. (2011) Anti-hypertensive drugs as disease-modifying agents for Parkinson's disease : evidence from observational studies and clinical trials. Cochrane Database of Systematic Reviews (No.11). CD008535. doi:10.1002/14651858.CD008535.pub2 ISSN 1469-493X.
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Official URL: http://dx.doi.org/10.1002/14651858.CD008535.pub2
Abstract
This is the protocol for a review and there is no abstract. The objectives are as follows:
This review will address the following questions:
1) Do anti-hypertensive drugs prevent the onset of PD? (We will seek primary prevention trials and epidemiological studies examining the association between anti-hypertensive drugs and PD to address this question.)
2) Are anti-hypertensive drugs disease modifying agents in PD - do they slow the progression of disease once PD is established? (We will seek secondary prevention trials to address this question.)
3) What are the adverse effects of taking anti-hypertensive drugs in patients with PD? (We will use studies included in question 2 above to examine this, along with any additional studies identified from the searching (including case studies and case series.))
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Parkinson's disease, Antiparkinsonian agents -- Effectiveness, Cardiovascular agents -- Effectiveness, Adrenergic beta blockers -- Effectiveness, Angiotensin converting enzyme -- Inhibitors -- Effectiveness, Hypotensive agents -- Effectiveness | ||||
Journal or Publication Title: | Cochrane Database of Systematic Reviews | ||||
Publisher: | John Wiley & Sons Ltd. | ||||
ISSN: | 1469-493X | ||||
Book Title: | Cochrane Database of Systematic Reviews | ||||
Official Date: | 9 November 2011 | ||||
Dates: |
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Number: | No.11 | ||||
Page Range: | CD008535 | ||||
DOI: | 10.1002/14651858.CD008535.pub2 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Description: | Protocol report |
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Funder: | Parkinson's Disease Society (PDS) |
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